Per allele hazard ratios (HR) and 95% confidence intervals (CI) of previously published breast cancer loci among BRCA2 mutation carriers from previous reports and from the iCOGS array, ordered by statistical significance of the region.



DOI:10.1371/journal.pgen.1003173.t001, Dimensions: 669159,


Dicks, Ed (1)
Wang, Qin (1)



  1. (1) University of Cambridge, grid.5335.0
  2. (2) Mayo Clinic, grid.66875.3a
  3. (3) Centre Hospitalier Métropole Savoie, grid.418064.f
  4. (4) Memorial Sloan Kettering Cancer Center, grid.51462.34
  5. (5) Karolinska Institute, grid.4714.6
  6. (6) Spanish National Cancer Research Centre, grid.7719.8
  7. (7) Centre Hospitalier Universitaire de Québec, grid.411081.d


1Reporting status of the SNP is either previously reported or novel to this report.2p-value was calculated based on the 1-degree of freedom score test statistic.3rs311499 could not be designed onto the iCOGS array. A surrogate (r2 = 1.0), rs311498, was included, however, and reported here.4Stronger associations were originally reported for the SNP, assuming a dominant or recessive model of the ‘risk allele’.