Grant

The Avon Longitudinal Study of Parents and Children: An international resource for populationgenomics and lifecourse epidemiology. Core Programme Support 2011-2015 and Core programme support 2014-2019

Funder: Medical Research Council

Dimensions: grant.4576591

Affiliations

Organisations

  1. (1) University of Bristol, grid.5337.2
  2. (2) University at Buffalo, State University of New York, grid.273335.3
  3. (3) Wellcome Sanger Institute, grid.10306.34
  4. (4) Newcastle University, grid.1006.7
  5. (5) University College London, grid.83440.3b
  6. (6) University of Oulu, grid.10858.34
  7. (7) University of Adelaide, grid.1010.0

Research Organisations

Abstract

For over 20 years Children of the 90s (or ALSPAC) has charted the health of 14,500 parents and children. Now in its third decade it has started to study the next generation, the children of the Children of the 90s. The study is unequalled by other population studies because of the breadth and depth of information it holds on participants from before birth over 20 years ago through to the present day. It is internationally renowned and used by researchers worldwide. The data allow researchers to study key periods of development, how certain conditions develop and change over time and are passed (or not) from one generation to the next, and how health is affected by the interplay between genes and other factors like smoking, where people live and the job they do. Our goals are to ensure the resource remains sustainable and open to researchers to use, and that participants remain engaged. We will continue to gather information from the original children through clinical assessments, questionnaires and record linkage, and will be recruiting and gathering data on the children of the children as well as merging genetic data and enhancing research in the exciting new field of epigenomics. Technical Summary The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective cohort study with unprecedented scope and detail of information on thousands of people from before birth through to early adulthood, on their parents and now on their children. It is an internationally valued resource at the forefront of population-based research. ALSPAC allows the investigation of developmental trajectories marking critical periods in human life, the genetic and epigenetic factors contributing to health and disease and the environmental exposures which form the context within which these processes act. As ALSPAC participants enter adulthood and start having children, the study's potential to contribute to scientific discovery is expanding, giving a greater capacity to explore links between current and future health and the intergenerational components of health and disease. ALSPAC is unequivocally the richest open-access epidemiological resource in the world. Our goals are to ensure that ALSPAC (i) is sustained, (ii) has participation maximised and (iii) is enhanced. These goals will be delivered by follow-up of the original cohort through clinic assessment, questionnaires and record linkage, data collection on their children, consolidation of GWAS data on all participants and the development of epigenomics research.

Resulting publications

Funding information

Funding period: 2011-2019

Funding amount: EUR 8176549

Grant number: MC_PC_15018

Research Categories

Main Subject Area

Fields of Research