Article open access publication

SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer

Carcinogenesis, Oxford University Press (OUP), ISSN 0143-3334

Volume 35, 1, 2014

DOI:10.1093/carcin/bgt304, Dimensions: pub.1000321017, PMID: 24031028,

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Organisations

  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) Umeå University, grid.12650.30
  3. (3) Karolinska Institute, grid.4714.6
  4. (4) Tianjin Medical University, grid.265021.2
  5. (5) Erasmus University Medical Center, grid.5645.2
  6. (6) Department of Clinical Sciences, University of Las Palmas de Gran Canaria-Canary Institute for Cancer Research (ICIC), 35016 Las Palmas, Spain and

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Denmark

Sweden

China

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Description

Anabolic signals such as androgens and the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis play an essential role in the normal development of the prostate but also in its malignant transformation. In this study, we investigated the role of suppressor of cytokine signaling 2 (SOCS2) as mediator of the cross talk between androgens and GH signals in the prostate and its potential role as tumor suppressor in prostate cancer (PCa). We observed that SOCS2 protein levels assayed by immunohistochemistry are elevated in hormone therapy-naive localized prostatic adenocarcinoma in comparison with benign tissue. In contrast, however, castration-resistant bone metastases exhibit reduced levels of SOCS2 in comparison with localized or hormone naive, untreated metastatic tumors. In PCa cells, SOCS2 expression is induced by androgens through a mechanism that requires signal transducer and activator of transcription 5 protein (STAT5) and androgen receptor-dependent transcription. Consequentially, SOCS2 inhibits GH activation of Janus kinase 2, Src and STAT5 as well as both cell invasion and cell proliferation in vitro. In vivo, SOCS2 limits proliferation and production of IGF-1 in the prostate in response to GH. Our results suggest that the use of GH-signaling inhibitors could be of value as a complementary treatment for castration-resistant PCa. SUMMARY: Androgen induced SOCS2 ubiquitin ligase expression and inhibited GH signaling as well as cell proliferation and invasion in PCa, whereas reduced SOCS2 was present in castration-resistant cases. GH-signaling inhibitors might be a complementary therapeutic option for advanced PCa.

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NORA University Profiles

University of Copenhagen

Danish Open Access Indicator

2013; 2014: Unused

Research area: Medicine

Danish Bibliometrics Indicator

2013: Level 2

Research area: Medicine

Dimensions Citation Indicators

Times Cited: 29

Field Citation Ratio (FCR): 9.38

Relative Citation ratio (RCR): 1.38

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