Article open access publication

pH-triggered drug release from biodegradable microwells for oral drug delivery

Biomedical Microdevices, Springer Nature, ISSN 1572-8781

Volume 17, 3, 2015

DOI:10.1007/s10544-015-9958-5, Dimensions: pub.1001147424, PMID: 25981751,

Affiliations

Organisations

  1. (1) Technical University of Denmark, grid.5170.3, DTU
  2. (2) University of Copenhagen, grid.5254.6, KU
  3. (3) Saarland University, grid.11749.3a

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Denmark

Germany

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Europe

Description

Microwells fabricated from poly-L-lactic acid (PLLA) were evaluated for their application as an oral drug delivery system using the amorphous sodium salt of furosemide (ASSF) as a model drug. Hot embossing of PLLA resulted in fabrication of microwells with an inner diameter of 240 μm and a height of 100 μm. The microwells were filled with ASSF using a modified screen printing technique, followed by coating of the microwell cavities with a gastro-resistant lid of Eudragit® L100. The release behavior of ASSF from the coated microwells was investigated using a μ-Diss profiler and a UV imaging system, and under conditions simulating the changing environment of the gastrointestinal tract. Biorelevant gastric medium (pH 1.6) was employed, after which a change to biorelevant intestinal release medium (pH 6.5) was carried out. Both μ-Diss profiler and UV imaging release experiments showed that sealing of microwell cavities with an Eudragit® layer prevented drug release in biorelevant gastric medium. An immediate release of the ASSF from coated microwells was observed in the intestinal medium. This pH-triggered release behavior demonstrates the future potential of PLLA microwells as a site-specific oral drug delivery system.

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NORA University Profiles

Technical University of Denmark

University of Copenhagen

Danish Open Access Indicator

2015: Realized

Research area: Medicine

Danish Bibliometrics Indicator

2015: Level 1

Research area: Medicine

Dimensions Citation Indicators

Times Cited: 18

Field Citation Ratio (FCR): 4.9

Relative Citation ratio (RCR): 1.15

Open Access Info

Green, Accepted