Article open access publication

Meta-analysis of routine blood tests as predictors of mortality in COPD

European Clinical Respiratory Journal, Taylor & Francis, ISSN 2001-8525

Volume 1, 1, 2014

DOI:10.3402/ecrj.v1.24110, Dimensions: pub.1001941545, PMC: PMC4629760, PMID: 26557244,

Affiliations

Organisations

  1. (1) Bispebjerg Hospital, grid.411702.1, Capital Region
  2. (2) Odense University Hospital, grid.7143.1, Southern Denmark Region
  3. (3) Rigshospitalet, grid.475435.4, Capital Region
  4. (4) Hvidovre Hospital, grid.411905.8, Capital Region

Countries

Denmark

Continents

Europe

Description

OBJECTIVE: The purpose of this study was to examine whether routine blood tests can be useful in predicting mortality in COPD patients. METHODS: Eligible studies were found through a search conducted in the PubMed and Embase databases, the Cochrane Library, and the Web of Knowledge. Twelve studies were included for the meta-analysis of five biochemical markers. Pooled odds ratios (ORs), matching 95% confidence intervals (CIs), and p-values for each of the biochemical markers were calculated using the random effect model. RESULTS: The following four examined biochemical markers were shown to be associated with mortality in patients suffering from COPD: anemia (OR=2.62, 95% CI: 1.60; 4.29, p=0.01), hypoalbuminemia (OR=2.90, 95% CI: 1.56; 5.40, p=0.0008), elevated NT-proBNP (OR=7.54, 95% CI: 4.04; 14.10, p<0.00001), and elevated cardiac troponin T (OR=3.10, 95% CI: 1.11; 8.25, p=0.03). hs-CRP was not found to be associated with increased mortality. CONCLUSION: In this study, we found that anemia, hypoalbuminemia, elevated NT-proBNP, and elevated cardiac troponin T were associated with increased mortality in patients suffering from COPD.

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Times Cited: 12

Field Citation Ratio (FCR): 3.49

Relative Citation ratio (RCR): 0.7

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