Article open access publication

Meta-analysis of routine blood tests as predictors of mortality in COPD

European Clinical Respiratory Journal, Taylor & Francis, ISSN 2001-8525

Volume 1, 1, 2014

DOI:10.3402/ecrj.v1.24110, Dimensions: pub.1001941545, PMC: PMC4629760, PMID: 26557244,



  1. (1) Bispebjerg Hospital, grid.411702.1, Capital Region
  2. (2) Odense University Hospital, grid.7143.1, Southern Denmark Region
  3. (3) Rigshospitalet, grid.475435.4, Capital Region
  4. (4) Hvidovre Hospital, grid.411905.8, Capital Region






OBJECTIVE: The purpose of this study was to examine whether routine blood tests can be useful in predicting mortality in COPD patients. METHODS: Eligible studies were found through a search conducted in the PubMed and Embase databases, the Cochrane Library, and the Web of Knowledge. Twelve studies were included for the meta-analysis of five biochemical markers. Pooled odds ratios (ORs), matching 95% confidence intervals (CIs), and p-values for each of the biochemical markers were calculated using the random effect model. RESULTS: The following four examined biochemical markers were shown to be associated with mortality in patients suffering from COPD: anemia (OR=2.62, 95% CI: 1.60; 4.29, p=0.01), hypoalbuminemia (OR=2.90, 95% CI: 1.56; 5.40, p=0.0008), elevated NT-proBNP (OR=7.54, 95% CI: 4.04; 14.10, p<0.00001), and elevated cardiac troponin T (OR=3.10, 95% CI: 1.11; 8.25, p=0.03). hs-CRP was not found to be associated with increased mortality. CONCLUSION: In this study, we found that anemia, hypoalbuminemia, elevated NT-proBNP, and elevated cardiac troponin T were associated with increased mortality in patients suffering from COPD.

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