Article

Treatment of adult patients with schizophrenia and complex mental health needs – A national clinical guideline

Nordic Journal of Psychiatry, Taylor & Francis, ISSN 1502-4725

Volume 70, 3, 2016

DOI:10.3109/08039488.2015.1074285, Dimensions: pub.1003357123, PMID: 26328910,

Affiliations

Organisations

  1. (1) a Danish Health and Medicines Authority and Mental Health Centre Glostrup , Denmark .
  2. (2) Danish Health and Medicines Authority, grid.416535.0
  3. (3) Bispebjerg Hospital, grid.411702.1, Capital Region
  4. (4) d Mental Health Centre Nordsjælland , Denmark .
  5. (5) e General Practice , Aars , Denmark .
  6. (6) f Aarhus University Hospital , Risskov , Denmark .
  7. (7) Mental Health Services, grid.466916.a, Central Denmark Region
  8. (8) h Frederiksbergpsykologen , Frederiksberg , Denmark .
  9. (9) University of Southern Denmark, grid.10825.3e, SDU
  10. (10) k Mental Health Centre Hvidovre , Denmark , and.
  11. (11) University of Copenhagen, grid.5254.6, KU

Countries

Denmark

Continents

Europe

Description

BACKGROUND AND AIM: The Danish Health and Medicines Authority assembled a group of experts to develop a national clinical guideline for patients with schizophrenia and complex mental health needs. Within this context, ten explicit review questions were formulated, covering several identified key issues. METHODS: Systematic literature searches were performed stepwise for each review question to identify relevant guidelines, systematic reviews/meta-analyses, and randomized controlled trials. The quality of the body of evidence for each review question was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Clinical recommendations were developed on the basis of the evidence, assessment of the risk-benefit ratio, and perceived patient preferences. RESULTS: Based on the identified evidence, a guideline development group (GDG) recommended that the following interventions should be offered routinely: antipsychotic maintenance therapy, family intervention and assertive community treatment. The following interventions should be considered: long-acting injectable antipsychotics, neurocognitive training, social cognitive training, cognitive behavioural therapy for persistent positive and/or negative symptoms, and the combination of cognitive behavioural therapy and motivational interviewing for cannabis and/or central stimulant abuse. SSRI or SNRI add-on treatment for persistent negative symptoms should be used only cautiously. Where no evidence was available, the GDG agreed on a good practice recommendation. CONCLUSIONS: The implementation of this guideline in daily clinical practice can facilitate good treatment outcomes within the population of patients with schizophrenia and complex mental health needs. The guideline does not cover all available interventions and should be used in conjunction with other relevant guidelines.

Research Categories

Main Subject Area

Fields of Research

Sustainable Development Goals

Links & Metrics

NORA University Profiles

University of Southern Denmark

University of Copenhagen

Aarhus University

Dimensions Citation Indicators

Times Cited: 14

Field Citation Ratio (FCR): 5.34

Relative Citation ratio (RCR): 1.23