Bifunctionalized dextrans for surface PEGylation via multivalent host–guest interactions

Carbohydrate Polymers, Elsevier, ISSN 1879-1344

Volume 133, 2015

DOI:10.1016/j.carbpol.2015.07.027, Dimensions: pub.1005897239, PMID: 26344304,



  1. (1) University Paris Est, ICMPE (UMR 7182), CNRS, UPEC, F-94320 Thiais, France
  2. (2) Aalborg University, grid.5117.2, AAU






The main goal of this work was to develop a supramolecular chemistry strategy to decorate interfaces with polyethylene glycol (PEG) grafts. A series of novel bifunctionalized dextrans, bearing 40-60 PEG pending chains and 12-24 hydrophobic adamantyl groups, have been prepared by copper(I)-catalyzed azide-alkyne cycloaddition. Their binding properties toward native βCD and βCD polymers were characterized both in solution and at interface using isothermal titration microcalorimetry and surface plasmon resonance. The polymers were found to form stable layers onto neutral and positively charged βCD-polymer films pre-adsorbed on gold surfaces, due to multivalent interpolymer host-guest interactions. The thickness and stability of the layers could be tuned by varying the ratio between the degrees of substitution by PEG and adamantyl groups.


Research Categories

Main Subject Area

Fields of Research

Links & Metrics

NORA University Profiles

Aalborg University

Danish Open Access Indicator

2015: Unused

Research area: Science & Technology

Danish Bibliometrics Indicator

2015: Level 1

Research area: Science & Technology

Dimensions Citation Indicators

Times Cited: 3

Field Citation Ratio (FCR): 0.36

Relative Citation ratio (RCR): 0.1