Article open access publication

Exercise Promotes Healthy Aging of Skeletal Muscle

Cell Metabolism, Elsevier, ISSN 1550-4131

Volume 23, 6, 2016

DOI:10.1016/j.cmet.2016.05.007, Dimensions: pub.1005981713, PMC: PMC5045036, PMID: 27304505,

Authors

Zierath, Juleen R. * (6) (7)

* Corresponding author

Affiliations

Organisations

  1. (1) University of Michigan, grid.214458.e
  2. (2) McGill University, grid.14709.3b
  3. (3) McGill University Health Centre, grid.63984.30
  4. (4) Birmingham VA Medical Center, grid.280808.a
  5. (5) University of Alabama at Birmingham, grid.265892.2
  6. (6) Karolinska Institute, grid.4714.6
  7. (7) University of Copenhagen, grid.5254.6, KU

Description

Primary aging is the progressive and inevitable process of bodily deterioration during adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and reduced muscle mass. Secondary aging refers to additional deleterious structural and functional age-related changes caused by diseases and lifestyle factors. Secondary aging can exacerbate deficits in mitochondrial function and muscle mass, concomitant with the development of skeletal muscle insulin resistance. Exercise opposes deleterious effects of secondary aging by preventing the decline in mitochondrial respiration, mitigating aging-related loss of muscle mass and enhancing insulin sensitivity. This review focuses on mechanisms by which exercise promotes "healthy aging" by inducing modifications in skeletal muscle.

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NORA University Profiles

University of Copenhagen

Danish Open Access Indicator

2016: Unused

Research area: Medicine

Danish Bibliometrics Indicator

2016: Level 2

Research area: Medicine

Dimensions Citation Indicators

Times Cited: 133

Field Citation Ratio (FCR): 44.86

Relative Citation ratio (RCR): 8.53

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