Article open access publication

The Role of Chromatin-Associated Proteins in Cancer

Annual Review of Cancer Biology, Annual Reviews, ISSN 2472-3428

Volume 1, 1, 2017

DOI:10.1146/annurev-cancerbio-050216-034422, Dimensions: pub.1006030467,

Authors

Helin, Kristian (1) (2) (3)
Minucci, Saverio (4) (5) (6)

Affiliations

Organisations

  1. (1) Biotech Research and Innovation Centre (BRIC),
  2. (2) Centre for Epigenetics, and
  3. (3) University of Copenhagen, grid.5254.6, KU
  4. (4) Department of Experimental Oncology,
  5. (5) European Institute of Oncology, grid.15667.33
  6. (6) University of Milan, grid.4708.b

Countries

Italy

Denmark

Continents

Europe

Description

The organization of the chromatin structure is essential for maintaining celltype- specific gene expression and therefore for cell identity. This structure is highly dynamic and is regulated by a large number of chromatin-associated proteins that are required for normal development and differentiation. Recurrent somatic mutations have been found with high frequency in genes coding for chromatin-associated proteins in cancer, and several of these are required for cancer maintenance. In this review, we discuss recent advances in understanding the role of chromatin-associated proteins in transcription, development, and cancer. Specifically, we focus on selected examples of proteins belonging to the histone methyltransferase, histone demethylase, or bromodomain families, for which specific small molecule inhibitors have been developed and are in either preclinical or clinical trials. Expected final online publication date for the Annual Review of Cancer Biology Volume 1 is March 04, 2017. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Research Categories

Main Subject Area

Fields of Research

Links & Metrics

NORA University Profiles

University of Copenhagen

Dimensions Citation Indicators

Times Cited: 4

Field Citation Ratio (FCR): 0.83

Open Access Info

Green, Published