Article

Antipsychotic medication and remission of psychotic symptoms 10years after a first-episode psychosis

Schizophrenia Research, Elsevier, ISSN 0920-9964

Volume 182, 2017

DOI:10.1016/j.schres.2016.10.030, Dimensions: pub.1006466725, PMID: 28277310,

Affiliations

Organisations

  1. (1) Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark
  2. (2) Lundbeck Foundation, grid.452548.a
  3. (3) Aarhus University Hospital, grid.154185.c, Central Denmark Region

Countries

Denmark

Continents

Europe

Description

BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up. METHODS: The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication. FINDINGS: 61% of the patients from the original cohort attended the 10-year follow up and 30% of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse. CONCLUSION: Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.

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NORA University Profiles

Aarhus University

Danish Open Access Indicator

2017: Unused

Research area: Medicine

Danish Bibliometrics Indicator

2017: Level 1

Research area: Medicine

Dimensions Citation Indicators

Times Cited: 37

Field Citation Ratio (FCR): 17.91

Relative Citation ratio (RCR): 4.88