Antipsychotic medication and remission of psychotic symptoms 10years after a first-episode psychosis

Schizophrenia Research, Elsevier, ISSN 0920-9964

Volume 182, 2017

DOI:10.1016/j.schres.2016.10.030, Dimensions: pub.1006466725, PMID: 28277310,



  1. (1) Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark
  2. (2) Lundbeck Foundation, grid.452548.a
  3. (3) Aarhus University Hospital, grid.154185.c, Central Denmark Region






BACKGROUND: Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up. METHODS: The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication. FINDINGS: 61% of the patients from the original cohort attended the 10-year follow up and 30% of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse. CONCLUSION: Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.


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