Article open access publication

A rare cause of severe hepatomegaly with an improving outcome

BMJ Case Reports, BMJ, ISSN 1757-790X

Volume 2014, apr03 1, 2014

DOI:10.1136/bcr-2013-203360, Dimensions: pub.1010298045, PMC: PMC3987551, PMID: 24700044,

Affiliations

Organisations

  1. (1) Odense University Hospital, grid.7143.1, Southern Denmark Region

Countries

Denmark

Continents

Europe

Description

A previously healthy 43-year-old man presented with dyspnoea, 15 kg weight loss, severe hepatomegaly and alkaline phosphatase at 5400 U/L. Examinations seemed to suggest cirrhosis, but blood samples did not show any signs of underlying liver disease. Liver biopsy revealed amyloid light chain (AL) amyloidosis and bone marrow showed multiple myeloma (MM). The patient was treated with drugs of choice cyclophosphamide, bortezomib and dexamethasone. He responded well to the treatment and so far achieved partial response. Previously MM was associated with poor prognosis but due to improved treatment for AL the patient can achieve a progression-free period with good quality of life.

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University of Southern Denmark

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Times Cited: 1

Field Citation Ratio (FCR): 0.32

Relative Citation ratio (RCR): 0

Open Access Info

Green, Published