Article

Revolution in the Polycomb hierarchy

Nature Structural & Molecular Biology, Springer Nature, ISSN 1545-9993

Volume 21, 7, 2014

DOI:10.1038/nsmb.2848, Dimensions: pub.1012141009, PMID: 24992222,

Authors

Helin, Kristian * (1) (2)

* Corresponding author

Affiliations

Organisations

  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) Kristian Helin is also at the Danish Stem Cell Center (DanStem), Copenhagen, Denmark.

Countries

Denmark

Continents

Europe

Description

Traditionally, maintenance of gene silencing by the Polycomb group proteins has been thought to involve recruitment of Polycomb repressive complex (PRC) 1 by PRC2-mediated trimethylation of K27 on histone H3. Three recent studies challenge this model by demonstrating that monoubiquitination of histone H2A, which is catalyzed by PRC1 complexes, can recruit PRC2 and potentiate its catalytic activity.

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NORA University Profiles

University of Copenhagen

Danish Open Access Indicator

2014: Unused

Research area: Science & Technology

Danish Bibliometrics Indicator

2014: Level 2

Research area: Science & Technology

Dimensions Citation Indicators

Times Cited: 23

Field Citation Ratio (FCR): 2.87

Relative Citation ratio (RCR): 0.57