Article open access publication

Preferences for prenatal tests for Down syndrome: an international comparison of the views of pregnant women and health professionals

European Journal of Human Genetics, Springer Nature, ISSN 1018-4813

Volume 24, 7, 2016

DOI:10.1038/ejhg.2015.249, Dimensions: pub.1014544274, PMC: PMC5070900, PMID: 26577044,



  1. (1) Great Ormond Street Hospital for Children NHS Foundation Trust, grid.424537.3
  2. (2) University of Calgary, grid.22072.35
  3. (3) University of British Columbia, grid.17091.3e
  4. (4) McMaster University, grid.25073.33
  5. (5) Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, grid.414818.0
  6. (6) National University of Singapore, grid.4280.e
  7. (7) Shaare Zedek Medical Center, grid.415593.f
  8. (8) Academic Medical Center, grid.5650.6
  9. (9) EMGO Institute for Health and Care Research, grid.466632.3
  10. (10) Department of Obstetrics and Gynecology, Fetal Medicine Unit, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
  11. (11) Centro de Genética Clínica, grid.421001.6
  12. (12) Cooperativa de Ensino Superior Politécnico e Universitário, grid.421335.2
  13. (13) Aarhus University Hospital, grid.154185.c, Central Denmark Region
  14. (14) National University Hospital of Iceland, grid.410540.4
  15. (15) University of Iceland, grid.14013.37
  16. (16) University College London, grid.83440.3b


Non-invasive prenatal testing is increasingly available worldwide and stakeholder viewpoints are essential to guide implementation. Here we compare the preferences of women and health professionals from nine different countries towards attributes of non-invasive and invasive prenatal tests for Down syndrome. A discrete choice experiment was used to obtain participants' stated preference for prenatal tests that varied according to four attributes: accuracy, time of test, risk of miscarriage, and type of information. Pregnant women and health professionals were recruited from Canada, Denmark, Iceland, Israel, Italy, the Netherlands, Portugal, Singapore, and the United Kingdom. A total of 2666 women's and 1245 health professionals' questionnaires were included in the analysis. Differences in preferences were seen between women and health professionals within and between countries. Overall, women placed greater emphasis on test safety and comprehensive information than health professionals, who emphasised accuracy and early testing. Differences between women's and health professionals' preferences are marked between countries. Varied approaches to implementation and service delivery are therefore needed and individual countries should develop guidelines appropriate for their own social and screening contexts.


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Research area: Medicine

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Times Cited: 23

Field Citation Ratio (FCR): 7.99

Relative Citation ratio (RCR): 3.21

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