Article open access publication

Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium

British Journal of Cancer, Springer Nature, ISSN 0007-0920

Volume 115, 1, 2016

DOI:10.1038/bjc.2016.153, Dimensions: pub.1017915943, PMC: PMC4931371, PMID: 27299959,



  1. (1) Roswell Park Cancer Institute, grid.240614.5
  2. (2) University at Buffalo, State University of New York, grid.273335.3
  3. (3) Medical University of South Carolina, grid.259828.c
  4. (4) Yale University, grid.47100.32
  5. (5) Duke University Hospital, grid.189509.c
  6. (6) German Cancer Research Center, grid.7497.d
  7. (7) Germany and University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  8. (8) University Cancer Center Hamburg, grid.412315.0
  9. (9) Harvard University, grid.38142.3c
  10. (10) University of Sydney, grid.1013.3
  11. (11) University of Pittsburgh, grid.21925.3d
  12. (12) Hannover Medical School, grid.10423.34
  13. (13) Department of Epidemiology, The Geisel School of Medicine at Dartmouth Medical, Hanover, NH, USA
  14. (14) University of Pittsburgh Cancer Institute, grid.478063.e
  15. (15) University of Kansas Medical Center, grid.412016.0
  16. (16) Independent Health, Buffalo, NY, USA
  17. (17) Mayo Clinic, grid.66875.3a
  18. (18) Cedars-Sinai Medical Center, grid.50956.3f
  19. (19) University of Copenhagen, grid.5254.6, KU
  20. (20) Danish Cancer Society, grid.417390.8
  21. (21) Aichi Cancer Center, grid.410800.d
  22. (22) Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  23. (23) QIMR Berghofer Medical Research Institute, grid.1049.c
  24. (24) Rutgers, The State University of New Jersey, grid.430387.b
  25. (25) University of Michigan, grid.214458.e
  26. (26) Memorial Sloan Kettering Cancer Center, grid.51462.34
  27. (27) Fred Hutchinson Cancer Research Center, grid.270240.3
  28. (28) University Medical Center Hamburg-Eppendorf, grid.13648.38
  29. (29) University of Southern California, grid.42505.36
  30. (30) University of Virginia, grid.27755.32
  31. (31) National Cancer Institute, grid.48336.3a
  32. (32) The University of Texas Health Science Center at Houston, grid.267308.8


BACKGROUND: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. METHODS: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. RESULTS: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. CONCLUSION: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.


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Research area: Medicine

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Times Cited: 17

Field Citation Ratio (FCR): 4.98

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