Article open access publication

Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia

Stem Cell Research, Elsevier, ISSN 1873-5061

Volume 17, 3, 2016

DOI:10.1016/j.scr.2016.10.006, Dimensions: pub.1018589104, PMID: 27789411,

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Organisations

  1. (1) Bioneer (Denmark), grid.424169.c
  2. (2) Mahidol University, grid.10223.32
  3. (3) University of Tübingen, grid.10392.39
  4. (4) Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
  5. (5) University of Copenhagen, grid.5254.6, KU

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Denmark

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Description

Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the gene coding the microtubule-associated protein tau (MAPT) can cause FTDP-17 but the underlying mechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required neuronal cell type. Here, we report the generation of iPSCs from a 44-year-old symptomatic woman carrying a S305I mutation in the MAPT-gene.

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University of Copenhagen

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2016: Realized

Research area: Medicine

Danish Bibliometrics Indicator

2016: Level 1

Research area: Medicine

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Times Cited: 1

Field Citation Ratio (FCR): 0.19

Relative Citation ratio (RCR): 0.07

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