Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology, Elsevier, ISSN 2212-4403

Volume 118, 4, 2014

DOI:10.1016/j.oooo.2014.06.008, Dimensions: pub.1020685753, PMID: 25240994,


* Corresponding author



  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) University of Southern Denmark, grid.10825.3e, SDU






OBJECTIVE: This study aimed to determine if the activity of the environmentally influenced cytochrome P450 enzyme CYP1A2, alone or in combination with CYP2D6*4 genotype, discriminates subgroups of oral lichen planus (OLP) according to lifestyle factors and clinical manifestations. STUDY DESIGN: A total of 111 patients with OLP were categorized according to normal, low, or high CYP1A2 activity and CYP2D6 4 genotype. Lifestyle parameters influencing the CYP1A2 activity and symptoms and manifestations of OLP were recorded. RESULTS: Of the 111 patients, 21% had low, 65% normal, and 14% high CYP1A2 activity. The high-CYP1A2-activity group was more exposed to CYP1A2 inducers than the low-CYP1A2-activity group. In the normal-CYP1A2-activity group, more patients had a CYP2D6 4 genotype (58%) (P = .02), and they presented more symptoms (P = .003) and gingival lesions (P = .03). More patients in the low-CYP1A2-activity group and without CYP2D6 4 genotype presented red lesions (P = .04). CONCLUSIONS: We suggest CYP2D6 4 genotype as a disease-susceptible genotype and low or high CYP1A2 activity levels as indicators of environmental influence in OLP subgroups.

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