Article

The novel biomarker of alternative macrophage activation, soluble mannose receptor (sMR/sCD206): Implications in multiple myeloma

Leukemia Research, Elsevier, ISSN 1873-5835

Volume 39, 9, 2015

DOI:10.1016/j.leukres.2015.06.003, Dimensions: pub.1023189166, PMID: 26169445,

Affiliations

Organisations

  1. (1) Aarhus University Hospital, grid.154185.c, Central Denmark Region
  2. (2) Aarhus University, grid.7048.b, AU
  3. (3) Odense University Hospital, grid.7143.1, Southern Denmark Region

Countries

Denmark

Continents

Europe

Description

Tumor-associated macrophages (TAMs) play an important role in the pathophysiology of human malignancies. They support growth of cancer cells by promoting angiogenesis, and by inhibiting tumour cell apoptosis and anti-tumor immune reactions. Several membrane proteins are well-described markers of human TAMs, including the haemoglobin scavenger receptor CD163 and the macrophage mannose receptor (MR/CD206). Interestingly, both CD163 and MR exist as soluble serum proteins (sCD163 and sMR) that may reflect the activation state of tissue macrophages, including TAMs. Here, we report the first data on sMR as a biomarker in patients with a malignant disease. We have measured concentrations of sMR in peripheral blood serum (n=104) from patients with newly diagnosed multiple myeloma (MM) by an enzyme-linked immunosorbent assay, and examined associations with data from medical records. At diagnosis, sMR levels were elevated in 27% of patients, and decreased after treatment. Further, sMR levels were associated with prognostic markers in MM, and elevated sMR (>0.43mg/L) was an independent marker of overall survival in a multivariate analysis (HR=2.20, P=0.006). Levels of sMR in blood samples showed significant association with sCD163, which may indicate common origin from CD163+MR+TAMs.

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Aarhus University

Danish Open Access Indicator

2015: Unused

Research area: Medicine

Danish Bibliometrics Indicator

2015: Level 1

Research area: Humanities; SUND

Dimensions Citation Indicators

Times Cited: 19

Field Citation Ratio (FCR): 4

Relative Citation ratio (RCR): 0.77