N-terminal pro-C-type natriuretic peptide in serum associated with bone destruction in patients with multiple myeloma

Biomarkers in Medicine, Future Science Group, ISSN 1752-0363

Volume 9, 7, 2015

DOI:10.2217/bmm.15.35, Dimensions: pub.1026198337, PMID: 26174842,



  1. (1) Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  2. (2) Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  3. (3) Aarhus University Hospital, grid.154185.c, Central Denmark Region
  4. (4) Linköping University Hospital, grid.411384.b
  5. (5) Section of Hematology, TromsøUniversity Hospital, Tromsø, Norway.
  6. (6) Odense University Hospital, grid.7143.1, Southern Denmark Region







AIM: To examine whether N-terminal proCNP concentrations in serum is associated with bone destruction in patients with multiple myeloma. MATERIALS & METHODS: N-terminal proCNP and biochemical bone markers were measured in 153 patients. Radiographic bone disease and skeletal-related events were evaluated at specific time-points. RESULTS: N-terminal proCNP concentrations increased with age. High N-terminal proCNP concentrations were associated with high-risk disease and renal impairment. Renal function explained 22% of the variation. N-terminal proCNP concentrations correlated with serum bone ALP and serum PINP, but lacked association with bone resorption markers, radiographic bone disease and skeletal-related events. CONCLUSION: Serum N-terminal proCNP are associated with bone formation activity in patients with multiple myeloma, but should be interpreted with caution in patients with renal impairment.

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Times Cited: 3

Field Citation Ratio (FCR): 1.11

Relative Citation ratio (RCR): 0.08