Article open access publication

An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE)

Sexual Medicine, Elsevier, ISSN 2050-1161

Volume 2, 2, 2014

DOI:10.1002/sm2.28, Dimensions: pub.1026283006, PMC: PMC4184677, PMID: 25356302,



  1. (1) Case Western Reserve University, grid.67105.35
  2. (2) Australian Center for Sexual Health Sydney NSW Australia
  3. (3) Utrecht University, grid.5477.1
  4. (4) Bağcılar Eğitim ve Araştırma Hastanesi, grid.489914.9
  5. (5) University of California, Davis, grid.27860.3b
  6. (6) National University of Singapore, grid.4280.e
  7. (7) University of Buenos Aires, grid.7345.5
  8. (8) London Clinic, grid.476752.5
  9. (9) Raymond Poincaré University Hospital, grid.414291.b
  10. (10) Tulane University, grid.265219.b
  11. (11) Mental Health Services, grid.466916.a, Central Denmark Region
  12. (12) Instituto H. Ellis, grid.419141.8
  13. (13) Erasmus MC‐Daniel den Hoed Cancer Center Rotterdam The Netherlands
  14. (14) University of L'Aquila, grid.158820.6
  15. (15) Deakin University, grid.1021.2
  16. (16) Montefiore Medical Center, grid.240283.f
  17. (17) Valparaiso University, grid.267748.8
  18. (18) University of California, San Francisco, grid.266102.1
  19. (19) Clinica de Urologia e Andrologia Belo‐Horizonte Minas‐Gerais Brazil


INTRODUCTION: In 2009, the International Society for Sexual Medicine (ISSM) convened a select panel of experts to develop an evidence-based set of guidelines for patients suffering from lifelong premature ejaculation (PE). That document reviewed definitions, etiology, impact on the patient and partner, assessment, and pharmacological, psychological, and combined treatments. It concluded by recognizing the continually evolving nature of clinical research and recommended a subsequent guideline review and revision every fourth year. Consistent with that recommendation, the ISSM organized a second multidisciplinary panel of experts in April 2013, which met for 2 days in Bangalore, India. This manuscript updates the previous guidelines and reports on the recommendations of the panel of experts. AIM: The aim of this study was to develop clearly worded, practical, evidenced-based recommendations for the diagnosis and treatment of PE for family practice clinicians as well as sexual medicine experts. METHOD: A comprehensive literature review was performed. RESULTS: This article contains the report of the second ISSM PE Guidelines Committee. It offers a new unified definition of PE and updates the previous treatment recommendations. Brief assessment procedures are delineated, and validated diagnostic and treatment questionnaires are reviewed. Finally, the best practices treatment recommendations are presented to guide clinicians, both familiar and unfamiliar with PE, in facilitating treatment of their patients. CONCLUSION: Development of guidelines is an evolutionary process that continually reviews data and incorporates the best new research. We expect that ongoing research will lead to a more complete understanding of the pathophysiology as well as new efficacious and safe treatments for this sexual dysfunction. We again recommend that these guidelines be reevaluated and updated by the ISSM in 4 years. Althof SE, McMahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, Becher E, Dean J, Giuliano F, Hellstrom WJG, Giraldi A, Glina S, Incrocci L, Jannini E, McCabe M, Parish S, Rowland D, Segraves RT, Sharlip I, and Torres LO. An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE). Sex Med 2014;2:60-90.

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