Article open access publication

Tracking the origins of Yakutian horses and the genetic basis for their fast adaptation to subarctic environments

Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences, ISSN 0027-8424

Volume 112, 50, 2015

DOI:10.1073/pnas.1513696112, Dimensions: pub.1026414280, PMC: PMC4687531, PMID: 26598656,

Affiliations

Organisations

  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) University College London, grid.83440.3b
  3. (3) University of California, Berkeley, grid.47840.3f
  4. (4) Technical University of Denmark, grid.5170.3, DTU
  5. (5) Joint Genome Institute, grid.451309.a
  6. (6) Centro Nacional de Análisis Genómico, grid.452341.5
  7. (7) Pompeu Fabra University, grid.5612.0
  8. (8) Kurchatov Institute, grid.18919.38
  9. (9) Agroscope, grid.417771.3
  10. (10) University of Bern, grid.5734.5
  11. (11) Université de Toulouse, University Paul Sabatier, Laboratoire d'Anthropobiologie Moléculaire et d'Imagerie de Synthèse, CNRS UMR 5288, 31000 Toulouse, France;
  12. (12) King Saud University, grid.56302.32
  13. (13) Yakutian Research Institute of Agriculture, 677002 Yakutsk, Sakha, Russia;
  14. (14) North-Eastern Federal University, grid.440700.7
  15. (15) University of Minnesota, grid.17635.36
  16. (16) Zoological Institute, grid.439287.3
  17. (17) Agrifood Research Finland, grid.417754.4
  18. (18) University of Eastern Finland, grid.9668.1

Description

Yakutia, Sakha Republic, in the Siberian Far East, represents one of the coldest places on Earth, with winter record temperatures dropping below -70 °C. Nevertheless, Yakutian horses survive all year round in the open air due to striking phenotypic adaptations, including compact body conformations, extremely hairy winter coats, and acute seasonal differences in metabolic activities. The evolutionary origins of Yakutian horses and the genetic basis of their adaptations remain, however, contentious. Here, we present the complete genomes of nine present-day Yakutian horses and two ancient specimens dating from the early 19th century and ∼5,200 y ago. By comparing these genomes with the genomes of two Late Pleistocene, 27 domesticated, and three wild Przewalski's horses, we find that contemporary Yakutian horses do not descend from the native horses that populated the region until the mid-Holocene, but were most likely introduced following the migration of the Yakut people a few centuries ago. Thus, they represent one of the fastest cases of adaptation to the extreme temperatures of the Arctic. We find cis-regulatory mutations to have contributed more than nonsynonymous changes to their adaptation, likely due to the comparatively limited standing variation within gene bodies at the time the population was founded. Genes involved in hair development, body size, and metabolic and hormone signaling pathways represent an essential part of the Yakutian horse adaptive genetic toolkit. Finally, we find evidence for convergent evolution with native human populations and woolly mammoths, suggesting that only a few evolutionary strategies are compatible with survival in extremely cold environments.

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University of Copenhagen

Technical University of Denmark

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2015: Realized

Research area: Science & Technology

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2015: Level 2

Research area: Science & Technology

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Times Cited: 70

Field Citation Ratio (FCR): 9.38

Relative Citation ratio (RCR): 2.3

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