Article

Maintaining cell identity: PRC2-mediated regulation of transcription and cancer

Nature Reviews Cancer, Springer Nature, ISSN 1474-1768

Volume 16, 12, 2016

DOI:10.1038/nrc.2016.83, Dimensions: pub.1027309366, PMID: 27658528,

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  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) The Francis Crick Institute, grid.451388.3

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Denmark

United Kingdom

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Europe

Description

Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb repressive complex 2 (PRC2), has attracted broad research attention in the past few years because of its involvement in the development and maintenance of many types of cancer and the use of specific EZH2 inhibitors in clinical trials. Several observations show that PRC2 can have both oncogenic and tumour-suppressive functions. We propose that these apparently opposing roles of PRC2 in cancer are a consequence of the molecular function of the complex in maintaining, rather than specifying, the transcriptional repression state of its several thousand target genes.

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NORA University Profiles

University of Copenhagen

Danish Open Access Indicator

2016: Unused

Research area: Science & Technology

Danish Bibliometrics Indicator

2016: Level 2

Research area: Science & Technology

Dimensions Citation Indicators

Times Cited: 175

Field Citation Ratio (FCR): 45.27

Relative Citation ratio (RCR): 7.22