Article open access publication

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Nature Genetics, Springer Nature, ISSN 1061-4036

Volume 46, 10, 2014

DOI:10.1038/ng.3094, Dimensions: pub.1027844356, PMC: PMC4383163, PMID: 25217961,

Authors

Han, Ying (4)
Wang, Zhaoming (3) (5)
Xia, Lucy (4)
Yu, Kai (3)
Goh, Chee (2)
Aly, Markus (12) (13)
Key, Tim J (15)
Nielsen, Sune F (19) (20)
Stanford, Janet L (23) (24)
Yeboah, Edward D (31) (32)
Tettey, Yao (31) (32)
Adjei, Andrew A (31) (32)
Tay, Evelyn (31) (32)
Park, Jong (38)
Ma, Jing (41)
Stampfer, Meir (6) (41)
Mucci, Lorelei (6) (41)
John, Esther M (42) (43)
Blot, William (47) (48)
Zheng, Wei (48)
Hennis, Anselm (50) (52)
Hsing, Ann W (42) (43)
Chu, Lisa (42) (43)
Teixeira, Manuel R (58) (59)
Li, Qiyuan (63)
Muir, Kenneth (64) (65)
Neal, David E (1) (66)
Giles, Graham G (67) (68)
Severi, Gianluca (67) (68) (69)
Eeles, Rosalind A * (2) (71)

* Corresponding author

Affiliations

Organisations

  1. (1) University of Cambridge, grid.5335.0
  2. (2) Institute of Cancer Research, grid.18886.3f
  3. (3) National Institutes of Health, grid.94365.3d
  4. (4) University of Southern California, grid.42505.36
  5. (5) Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, SAIC-Frederick, Inc., Frederick, Maryland, USA
  6. (6) Harvard University, grid.38142.3c
  7. (7) University of Hawaii at Manoa, grid.410445.0
  8. (8) Tampere University, grid.502801.e
  9. (9) University of Turku, grid.1374.1
  10. (10) Tampere University Hospital, grid.412330.7
  11. (11) Wake Forest University, grid.241167.7
  12. (12) Danderyds sjukhus, grid.412154.7
  13. (13) Karolinska Institute, grid.4714.6
  14. (14) University of Bristol, grid.5337.2
  15. (15) University of Oxford, grid.4991.5
  16. (16) Imperial College London, grid.7445.2
  17. (17) German Cancer Research Center, grid.7497.d
  18. (18) RIKEN, grid.7597.c
  19. (19) Herlev Hospital, grid.411900.d, Capital Region
  20. (20) University of Copenhagen, grid.5254.6, KU
  21. (21) Department of Urology, Copenhagen Prostate Cancer Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  22. (22) Mayo Clinic, RochesterMinnesota, USA
  23. (23) University of Washington, grid.34477.33
  24. (24) Fred Hutchinson Cancer Research Center, grid.270240.3
  25. (25) Translational Pathology, Cedars-Sinai, Los AngelesCalifornia, USA
  26. (26) Prostate Center, Vancouver, British Columbia, Canada
  27. (27) American Cancer Society, grid.422418.9
  28. (28) University Hospital Ulm, grid.410712.1
  29. (29) Rechts der Isar Hospital, grid.15474.33
  30. (30) The University of Texas MD Anderson Cancer Center, grid.240145.6
  31. (31) Korle Bu Teaching Hospital, grid.415489.5
  32. (32) University of Ghana, grid.8652.9
  33. (33) Westat (United States), grid.280561.8
  34. (34) University of California, Berkeley, grid.47840.3f
  35. (35) George E. Wahlen Department of VA Medical Center, grid.413886.0
  36. (36) University of Utah, grid.223827.e
  37. (37) Pomeranian Medical University, grid.107950.a
  38. (38) Moffitt Cancer Center, grid.468198.a
  39. (39) Johns Hopkins University, grid.21107.35
  40. (40) Krebsregister Saarland, grid.482902.5
  41. (41) Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
  42. (42) Cancer Prevention Institute of California, grid.280669.3
  43. (43) Stanford University, grid.168010.e
  44. (44) University of Illinois at Chicago, grid.185648.6
  45. (45) Northwestern University, grid.16753.36
  46. (46) University of Surrey, grid.5475.3
  47. (47) International Epidemiology Institute, grid.419344.f
  48. (48) Vanderbilt University, grid.152326.1
  49. (49) National Institute for Health and Welfare, grid.14758.3f
  50. (50) Stony Brook University, grid.36425.36
  51. (51) Translational Genomics Research Institute, grid.250942.8
  52. (52) University of the West Indies, grid.412886.1
  53. (53) Division of Urologic Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
  54. (54) Henry Ford Hospital, grid.413103.4
  55. (55) Cleveland Clinic, grid.239578.2
  56. (56) Queensland University of Technology, grid.1024.7
  57. (57) QIMR Berghofer Medical Research Institute, grid.1049.c
  58. (58) University of Porto, grid.5808.5
  59. (59) Portuguese Oncology Institute, grid.418711.a
  60. (60) Medical University of Sofia, grid.410563.5
  61. (61) University of California, San Francisco, grid.266102.1
  62. (62) National Cancer Institute, grid.48336.3a
  63. (63) Dana-Farber Cancer Institute, grid.65499.37
  64. (64) University of Manchester, grid.5379.8
  65. (65) University of Warwick, grid.7372.1
  66. (66) Cancer Research UK Cambridge Institute, grid.470869.4
  67. (67) University of Melbourne, grid.1008.9
  68. (68) Cancer Council Victoria, grid.3263.4
  69. (69) Human Genetics Foundation, grid.428948.b
  70. (70) Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan
  71. (71) Royal Marsden National Health Service (NHS) Foundation Trust, London and Sutton, UK

Description

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

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University of Copenhagen

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2014: Unused

Research area: Medicine

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2014: Level 2

Research area: Medicine

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Times Cited: 288

Field Citation Ratio (FCR): 64.37

Relative Citation ratio (RCR): 10.11

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Green, Published