Article open access publication

Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

Diabetes, American Diabetes Association, ISSN 0012-1797

Volume 64, 7, 2015

DOI:10.2337/db14-1629, Dimensions: pub.1029883240, PMC: PMC4876751, PMID: 25720386,

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  1. (1) Albert Einstein College of Medicine, grid.251993.5
  2. (2) Harvard University, grid.38142.3c
  3. (3) University of Copenhagen, grid.5254.6, KU
  4. (4) MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital and University of Cambridge, Cambridge, U.K
  5. (5) Erasmus University Medical Center, grid.5645.2
  6. (6) University of Southampton, grid.5491.9
  7. (7) University of Leicester, grid.9918.9
  8. (8) Harokopio University, grid.15823.3d
  9. (9) Helmholtz Zentrum München, grid.4567.0
  10. (10) University of Split, grid.38603.3e
  11. (11) Wellcome Sanger Institute, grid.10306.34
  12. (12) University of Oulu, grid.10858.34
  13. (13) Leiden University, grid.5132.5
  14. (14) Leipzig University, grid.9647.c
  15. (15) Kuopion Liikuntalääketieteen Tutkimuslaitos, grid.419013.e
  16. (16) University of Eastern Finland, grid.9668.1
  17. (17) Capital Medical University, grid.24696.3f
  18. (18) Karolinska Institute, grid.4714.6
  19. (19) Yamaguchi University, grid.268397.1
  20. (20) Turku University Hospital, grid.410552.7
  21. (21) University of Turku, grid.1374.1
  22. (22) University of Bristol, grid.5337.2
  23. (23) University of Glasgow, grid.8756.c
  24. (24) Finnish Institute of Occupational Health, grid.6975.d
  25. (25) Augusta University, grid.410427.4
  26. (26) University Medical Center Groningen, grid.4494.d
  27. (27) Hokkaido Nursing College, Chuo-ku, Sapporo, Japan
  28. (28) Icahn School of Medicine at Mount Sinai, grid.59734.3c
  29. (29) Brigham and Women's Hospital, grid.62560.37

Description

The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1-18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 × 10(-4)), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 × 10(-4)): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 × 10(-10)) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.

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Times Cited: 52

Field Citation Ratio (FCR): 14.74

Relative Citation ratio (RCR): 2.69

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