Article open access publication

Ten-Year Follow-up of the OPUS Specialized Early Intervention Trial for Patients With a First Episode of Psychosis

Schizophrenia Bulletin, Oxford University Press (OUP), ISSN 0586-7614

Volume 41, 3, 2015

DOI:10.1093/schbul/sbu155, Dimensions: pub.1030092295, PMC: PMC4393691, PMID: 25381449,



  1. (1) Mental Health Center Copenhagen, Copenhagen University Hospital , Copenhagen , Denmark ;
  2. (2) Lundbeck Foundation, grid.452548.a
  3. (3) Mental Health Center North Zealand, Copenhagen University Hospital , Copenhagen , Denmark ;
  4. (4) Child & Adolescent Mental Health Center, Copenhagen University Hospital , Glostrup , Denmark ;
  5. (5) Aarhus University Hospital, grid.154185.c, Central Denmark Region






INTRODUCTION: Specialized early intervention programs such as The Danish OPUS treatment are efficient in treating patients with a first episode of psychosis (FEP) at least after 2 and 5 years. Few studies have examined long-term outcomes of these interventions. AIM: To examine the effect of 2 years of OPUS vs treatment as usual (TAU) within an FEP cohort, 10 years after inclusion into the OPUS trial. METHODS: From 1998 to 2000, participants were randomized to OPUS or TAU. Ten years later, we conducted comprehensive interviews and performed register-based follow-up on all participants in national Danish registers. We analyzed participants according to the intention-to-treat principle. RESULTS: Of the 547 participants included in the study, 347 (63.4%) took part in this follow-up. While there was evidence of a differential 10-year course in the development of negative symptoms, psychiatric bed days, and possibly psychotic symptoms in favor of OPUS treatment, differences were driven by effects at earlier follow-ups and had diminished over time. Statistically significant differences in the course of use of supported housing were present even after 8-10 years. There were no differences between OPUS and TAU regarding income, work-related outcomes, or marital status. CONCLUSION: Most of the positive short-term effects of the OPUS intervention had diminished or vanished at this long-term follow-up. We observed a clear tendency that OPUS treatment leads to fewer days in supported housing. There is a need for further studies investigating if extending the intervention will improve outcomes more markedly at long-term follow-ups.

Research Categories

Main Subject Area

Fields of Research

Links & Metrics

NORA University Profiles

Aarhus University

Dimensions Citation Indicators

Times Cited: 63

Field Citation Ratio (FCR): 20.25

Relative Citation ratio (RCR): 4.84

Open Access Info