Article open access publication

Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries

BMC Infectious Diseases, Springer Nature, ISSN 1471-2334

Volume 16, 1, 2016

DOI:10.1186/s12879-016-1575-2, Dimensions: pub.1032261865, PMC: PMC4880878, PMID: 27230666,

Affiliations

Organisations

  1. (1) University of Georgia, grid.213876.9
  2. (2) Swiss Centre for Scientific Research, grid.462846.a
  3. (3) Université Félix Houphouët-Boigny, grid.410694.e
  4. (4) Swiss Tropical and Public Health Institute, grid.416786.a
  5. (5) University of Basel, grid.6612.3
  6. (6) University of Copenhagen, grid.5254.6, KU
  7. (7) National Institute for Medical Research, grid.416716.3
  8. (8) Imperial College London, grid.7445.2
  9. (9) Catholic University of Mozambique, grid.287982.e
  10. (10) Kenya Medical Research Institute, grid.33058.3d
  11. (11) Centers for Disease Control and Prevention, grid.416738.f
  12. (12) Réseau International Schistosomoses, Environnement, Aménagement et Lutte (RISEAL-Niger), Niamey, Niger
  13. (13) Case Western Reserve University, grid.67105.35

Description

BACKGROUND: The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was established in 2008 to answer strategic questions about schistosomiasis control. For programme managers, a high-priority question is: what are the most cost-effective strategies for delivering preventive chemotherapy (PCT) with praziquantel (PZQ)? This paper describes the process SCORE used to transform this question into a harmonized research protocol, the study design for answering this question, the village eligibility assessments and data resulting from the first year of the study. METHODS: Beginning in 2009, SCORE held a series of meetings to specify empirical questions and design studies related to different schedules of PCT for schistosomiasis control in communities with high (gaining control studies) and moderate (sustaining control studies) prevalence of Schistosoma infection among school-aged children. Seven studies are currently being implemented in five African countries. During the first year, villages were screened for eligibility, and data were collected on prevalence and intensity of infection prior to randomisation and the implementation of different schemes of PZQ intervention strategies. RESULTS: These studies of different treatment schedules with PZQ will provide the most comprehensive data thus far on the optimal frequency and continuity of PCT for schistosomiasis infection and morbidity control. CONCLUSIONS: We expect that the study outcomes will provide data for decision-making for country programme managers and a rich resource of information to the schistosomiasis research community. TRIAL REGISTRATION: The trials are registered at International Standard Randomised Controlled Trial registry (identifiers: ISRCTN99401114 , ISRCTN14849830 , ISRCTN16755535 , ISRCTN14117624 , ISRCTN95819193 and ISRCTN32045736 ).

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Times Cited: 45

Field Citation Ratio (FCR): 15.07

Relative Citation ratio (RCR): 4.57

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