Article open access publication

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice

Blood, American Society of Hematology, ISSN 1528-0020

Volume 125, 13, 2015

DOI:10.1182/blood-2014-08-596734, Dimensions: pub.1032481734, PMC: PMC4467872, PMID: 25655602,

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  1. (1) Boston Children's Hospital, grid.2515.3
  2. (2) Harvard University, grid.38142.3c
  3. (3) University of Copenhagen, grid.5254.6, KU
  4. (4) University College London, grid.83440.3b

Description

Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer; however, its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is overexpressed in acute myeloid leukemias. Constitutive genetic deletion of Jarid1b did not impact steady-state hematopoiesis. In contrast, acute deletion of Jarid1b from bone marrow increased peripheral blood T cells and, following secondary transplantation, resulted in loss of bone marrow reconstitution. Our results reveal that deletion of Jarid1b compromises hematopoietic stem cell (HSC) self-renewal capacity and suggest that Jarid1b is a positive regulator of HSC potential.

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University of Copenhagen

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Times Cited: 29

Field Citation Ratio (FCR): 9.42

Relative Citation ratio (RCR): 0.84

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