Article

Regional tumour glutamine supply affects chromatin and cell identity

Nature Cell Biology, Springer Nature, ISSN 1476-4679

Volume 18, 10, 2016

DOI:10.1038/ncb3414, Dimensions: pub.1037431122, PMID: 27684506,

Authors

Helin, Kristian * (1) (2)

* Corresponding author

Affiliations

Organisations

  1. (1) Jonas W. Højfeldt and Kristian Helin are at the Biotech Research and Innovation Centre, University of Copenhagen, 2200, Denmark; at the Centre for Epigenetics, University of Copenhagen, 2200, Denmark; and at the Danish Stem Cell Center (Danstem), Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Denmark
  2. (2) University of Copenhagen, grid.5254.6, KU

Countries

Denmark

Continents

Europe

Description

Limited perfusion of solid tumours produces a nutrient-deprived tumour core microenvironment. Low glutamine levels in the tumour core are now shown to lead to reduced levels of α-ketoglutarate and decreased histone demethylase activity, thereby promoting a less differentiated and more therapy-resistant state of the tumour cells.

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University of Copenhagen

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Times Cited: 2

Field Citation Ratio (FCR): 0.52

Relative Citation ratio (RCR): 0.07