Article open access publication

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

Cell, Elsevier, ISSN 0092-8674

Volume 158, 6, 2014

DOI:10.1016/j.cell.2014.08.011, Dimensions: pub.1047717783, PMID: 25215487,

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  1. (1) Weizmann Institute of Science, grid.13992.30
  2. (2) University of Copenhagen, grid.5254.6, KU
  3. (3) Aarhus University Hospital, grid.154185.c, Central Denmark Region
  4. (4) Department of Hematology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
  5. (5) VU University Medical Center, grid.16872.3a
  6. (6) Massachusetts General Hospital, grid.32224.35
  7. (7) Department of Pathology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
  8. (8) Swiss Federal Institute of Technology in Lausanne, grid.5333.6

Description

A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the opposite signature. Correspondingly, we found that genes serving cell-autonomous functions and genes involved in multicellularity obey distinct codon usage. Proliferation-induced and differentiation-induced tRNAs often carry anticodons that correspond to the codons enriched among the cell-autonomous and the multicellularity genes, respectively. Because mRNAs of cell-autonomous genes are induced in proliferation and cancer in particular, the concomitant induction of their codon-enriched tRNAs suggests coordination between transcription and translation. Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Hence, we describe the existence of two distinct translation programs that operate during proliferation and differentiation.

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University of Copenhagen

Aarhus University

Danish Open Access Indicator

2014: Blocked

Research area: Medicine

Danish Bibliometrics Indicator

2014: Level 2

Research area: Medicine

Dimensions Citation Indicators

Times Cited: 233

Field Citation Ratio (FCR): 27.94

Relative Citation ratio (RCR): 6.99

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