Article open access publication

Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H266

Stem Cell Research, Elsevier, ISSN 1873-5061

Volume 16, 1, 2016

DOI:10.1016/j.scr.2015.12.029, Dimensions: pub.1050460417, PMID: 27345805,

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  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) Neurogenetic Research Laboratory, Danish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
  3. (3) Bioneer (Denmark), grid.424169.c
  4. (4) Mahidol University, grid.10223.32

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Denmark

Thailand

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Europe

Asia

Description

Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease primarily affecting the cerebellum. Very little is known about the molecular mechanisms underlying the disease and, to date, no cure or treatment is available. Here, we demonstrate the generation of an induced pluripotent stem cell (iPSC) line of a SCA2 patient. The selected clone has been proven to be a bona fide iPSC line, which retains a normal karyotype. Due to its differentiation potential into neurons, this iPSC line will be a valuable tool in studying a disease-specific phenotype of SCA2.

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University of Copenhagen

Danish Open Access Indicator

2016: Realized

Research area: Medicine

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2016: Level 1

Research area: Medicine

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Times Cited: 2

Field Citation Ratio (FCR): 0.42

Relative Citation ratio (RCR): 0.15

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