Article

Association between Attention-Deficit Hyperactivity Disorder in childhood and schizophrenia later in adulthood

European Psychiatry, Cambridge University Press (CUP), ISSN 1778-3585

Volume 29, 4, 2014

DOI:10.1016/j.eurpsy.2013.06.004, Dimensions: pub.1050610675, PMID: 24016863,

Authors

Dalsgaard, S. * (1) (2) (3) (4)
Mortensen, P.B. (2) (3)
Nordentoft, M. (3) (5)

* Corresponding author

Affiliations

Organisations

  1. (1) Department for Child and Adolescent Psychiatry, Hospital of Telemark, Kragerø, Norway
  2. (2) Aarhus University, grid.7048.b, AU
  3. (3) Lundbeck Foundation, grid.452548.a
  4. (4) Aarhus University Hospital, grid.154185.c, Central Denmark Region
  5. (5) University of Copenhagen, grid.5254.6, KU

Countries

Denmark

Continents

Europe

Description

PURPOSE: To estimate the risk of schizophrenia in adulthood among children and adolescents with ADHD compared to the background population. SUBJECTS/MATERIALS AND METHODS: Two hundred and eight youths with ADHD (183 boys; 25 girls) were followed prospectively. Diagnoses of schizophrenia were obtained from The Danish Psychiatric Central Register. The relative risk (RR) of schizophrenia for cases with ADHD, compared to the normal population, was calculated as risk ratios. Hazard ratios (HR's) by Cox regression were calculated in the predictor analyses. RESULTS: Mean age for ADHD cases at follow-up was 31.1years. Schizophrenia diagnoses were given to 3.8% of these cases. Compared to the general population, RR of schizophrenia in cases with ADHD was 4.3 (95% CI 1.9-8.57). DISCUSSION AND CONCLUSION: This prospective follow-up study found children with ADHD to be at higher risk of later schizophrenia than controls. If replicated, these results warrant increased focus on the possible emergence symptoms of schizophrenia or schizophreniform psychosis during clinical follow-up of patients with ADHD.

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NORA University Profiles

Aarhus University

University of Copenhagen

Danish Open Access Indicator

2014: Unused

Research area: Medicine

Danish Bibliometrics Indicator

2014: Level 1

Research area: Medicine

Dimensions Citation Indicators

Times Cited: 59

Field Citation Ratio (FCR): 16.53

Relative Citation ratio (RCR): 3.58