- (1) University of Copenhagen, grid.5254.6, KU
- (2) Department of Psychiatry, Oslo University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166. 0407 Oslo, Norway
- (3) Psychiatric Centre Copenhagen, Department O, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark
- (4) Department of Medical Genetics, Oslo University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166. 0407 Oslo, Norway
- (5) Department of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen University Hospital, Boserupvej 2, DK-4000 Roskilde, Denmark
- (6) Aarhus University Hospital, grid.154185.c, Central Denmark Region
- (7) Technical University of Denmark, grid.5170.3, DTU
The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.