Article

Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11.

Journal of the American Chemical Society, American Chemical Society (ACS), ISSN 1520-5126

Volume 138, 1, 2016

DOI:10.1021/jacs.5b11357, Dimensions: pub.1055874825, PMID: 26684612,

Affiliations

Organisations

  1. (1) Singapore Bioimaging Consortium, grid.452254.0
  2. (2) Nanyang Technological University, grid.59025.3b
  3. (3) National University of Singapore, grid.4280.e
  4. (4) Aalborg University, grid.5117.2, AAU
  5. (5) Aarhus University, grid.7048.b, AU
  6. (6) University of Copenhagen, grid.5254.6, KU

Countries

Singapore

Denmark

Continents

Asia

Europe

Description

Bacterial biofilms are responsible for a wide range of persistent infections. In the clinic, diagnosis of biofilm-associated infections relies heavily on culturing methods, which fail to detect nonculturable bacteria. Identification of novel fluorescent probes for biofilm imaging will greatly facilitate diagnosis of pathogenic bacterial infection. Herein, we report a novel fluorescent probe, CDy11 (compound of designation yellow 11), which targets amyloid in the Pseudomonas aeruginosa biofilm matrix through a diversity oriented fluorescent library approach (DOFLA). CDy11 was further demonstrated for in vivo imaging of P. aeruginosa in implant and corneal infection mice models.

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NORA University Profiles

Aalborg University

Aarhus University

University of Copenhagen

Danish Open Access Indicator

2016: Blocked

Research area: Science & Technology

Danish Bibliometrics Indicator

2016: Level 2

Research area: Science & Technology

Dimensions Citation Indicators

Times Cited: 40

Relative Citation ratio (RCR): 2.28