Article

Metabolomics investigation to shed light on cheese as a possible piece in the French paradox puzzle.

Journal of Agricultural and Food Chemistry, American Chemical Society (ACS), ISSN 0021-8561

Volume 63, 10, 2015

DOI:10.1021/jf505878a, Dimensions: pub.1055915162, PMID: 25727903,

Affiliations

Organisations

  1. (1) Aarhus University, grid.7048.b, AU
  2. (2) University of Copenhagen, grid.5254.6, KU

Countries

Denmark

Continents

Europe

Description

An NMR-based metabolomics approach was used to investigate the differentiation between subjects consuming cheese or milk and to elucidate the potential link to an effect on blood cholesterol level. Fifteen healthy young men participated in a full crossover study during which they consumed three isocaloric diets with similar fat contents that were either (i) high in milk, (ii) high in cheese with equal amounts of dairy calcium, or (iii) a control diet for 14 days. Urine and feces samples were collected and analyzed by NMR-based metabolomics. Cheese and milk consumption decreased urinary choline and TMAO levels and increased fecal excretion of acetate, propionate, and lipid. Compared with milk intake, cheese consumption significantly reduced urinary citrate, creatine, and creatinine levels and significantly increased the microbiota-related metabolites butyrate, hippurate, and malonate. Correlation analyses indicated that microbial and lipid metabolism could be involved in the dairy-induced effects on blood cholesterol level.

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NORA University Profiles

Aarhus University

University of Copenhagen

Danish Open Access Indicator

2015: Blocked

Research area: Science & Technology

Danish Bibliometrics Indicator

2015: Level 2

Research area: Science & Technology

Dimensions Citation Indicators

Times Cited: 56

Relative Citation ratio (RCR): 3.45