Article

Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels.

Biochemical Society Transactions, Portland Press, ISSN 1470-8752

Volume 43, 3, 2015

DOI:10.1042/bst20150040, Dimensions: pub.1056717885, PMID: 26009201,

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  1. (1) University of Copenhagen, grid.5254.6, KU

Countries

Denmark

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Europe

Description

Connexin43 (Cx43) generates intercellular gap junction channels involved in, among others, cardiac and brain function. Gap junctions are formed by the docking of two hemichannels from neighbouring cells. Undocked Cx43 hemichannels can upon different stimuli open towards the extracellular matrix and allow transport of molecules such as fluorescent dyes and ATP. A range of phosphorylated amino acids have been detected in the C-terminus of Cx43 and their physiological role has been intensively studied both in the gap junctional form of Cx43 and in its hemichannel configuration. We present the current knowledge of protein kinase C (PKC)-dependent regulation of Cx43 and discuss the divergent results.

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University of Copenhagen

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Times Cited: 10

Field Citation Ratio (FCR): 1.45

Relative Citation ratio (RCR): 0.91