Article open access publication

Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204

Frontiers in Molecular Neuroscience, Frontiers, ISSN 1662-5099

Volume 10, 2017

DOI:10.3389/fnmol.2017.00031, Dimensions: pub.1083756721, PMC: PMC5299138, PMID: 28232790,

Affiliations

Organisations

  1. (1) Aarhus University, grid.7048.b, AU
  2. (2) University Medical Center Utrecht, grid.7692.a
  3. (3) University of Southern Denmark, grid.10825.3e, SDU
  4. (4) Randers Regional Hospital, grid.415677.6, Central Denmark Region

Countries

Denmark

Netherlands

Continents

Europe

Description

The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. In vivo modulation of miRNA expression in mouse embryos confirmed that miR-34c and miR-204 can control neuronal migration and cortical morphogenesis, presumably by posttranscriptional regulation of DCX.

Funders

Research Categories

Main Subject Area

Fields of Research

Links & Metrics

NORA University Profiles

Aarhus University

University of Southern Denmark

Dimensions Citation Indicators

Times Cited: 3

Field Citation Ratio (FCR): 1.07

Relative Citation ratio (RCR): 0.19

Open Access Info

Pure Gold