Article

Host–guest interaction and structural ordering in polymeric nanoassemblies: Influence of molecular design

International Journal of Pharmaceutics, Elsevier, ISSN 0378-5173

Volume 531, 2, 2017

DOI:10.1016/j.ijpharm.2017.02.061, Dimensions: pub.1083899431, PMID: 28242378,

Affiliations

Organisations

  1. (1) University Paris Est, ICMPE (UMR 7182), CNRS, UPEC, F- 94320 Thiais, France
  2. (2) Aarhus University, grid.7048.b, AU
  3. (3) Aalborg University, grid.5117.2, AAU

Countries

Denmark

Continents

Europe

Description

Host-guest nanoassemblies made from spontaneous self-association of host and guest polymers in aqueous solutions have been studied. The specific motivation behind this work was to clarify the impact of the molecular design of the polymers on the interactions between them and on the inner structure of the resulting nanoassemblies. The polymers were composed of a dextran backbone, functionalized with either pendant β-cyclodextrin (CD) or adamantyl (Ada). Those groups were connected to the backbone either directly or with hydrophilic polyethylene glycol (PEG) spacers. To study the impact of those spacers we have proposed a synthetic pathway to new guest polymers. The latter relied on the use of thiol-substituted dextrans as a scaffold, which is subsequently transformed into PEG-Ada grafted guest polymers via nucleophile-mediated thiol-click reaction. Surface plasmon resonance (SPR) studies evidenced strong mutual affinities between the host and guest polymers and showed that the stoichiometry was close to the ideal one (CD/Ada = 1/1) when PEG spacers were introduced. The structure of the nanoassemblies was studied by a combination of dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS). The nature of the individual host or guest polymers has a strong impact on the size and internal structure of the resulting nanoassemblies. The presence of PEG spacers in the polymers led to smaller and less compact nanoassemblies, as evidenced by their large correlation length values (4-20nm compared to 2nm without PEG spacers). At the same time, all types of nanoassemblies appear to have radial density distribution with denser cores and pending polymer chains at the periphery. This study, centered on the influence of the molecular design on the host-guest interactions and structural ordering in polymeric nanoassemblies, will help to tailor host-guest nanoassemblies with attractive drug delivery profiles.

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NORA University Profiles

Aarhus University

Aalborg University

Danish Open Access Indicator

2017: Unused

Research area: Science & Technology

Danish Bibliometrics Indicator

2017: Level 1

Research area: Science & Technology

Dimensions Citation Indicators

Times Cited: 4

Field Citation Ratio (FCR): 1.15

Relative Citation ratio (RCR): 0.57