Article open access publication

Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis

Angewandte Chemie, Wiley, ISSN 1521-3757

Volume 129, 14, 2017

DOI:10.1002/ange.201700052, Dimensions: pub.1084008078,



  1. (1) Technical University of Denmark, grid.5170.3, DTU
  2. (2) University of Copenhagen, grid.5254.6, KU
  3. (3) TU Wien, grid.5329.d







Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.

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