Article open access publication

Exercise and cancer: from “healthy” to “therapeutic”?

Cancer Immunology, Immunotherapy, Springer Nature, ISSN 1432-0851

Volume 66, 5, 2017

DOI:10.1007/s00262-017-1985-z, Dimensions: pub.1084020224, PMC: PMC5406418, PMID: 28324125,

Authors

thor Straten, Per * (1) (2)

* Corresponding author

Affiliations

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  1. (1) Herlev Hospital, grid.411900.d, Capital Region
  2. (2) University of Copenhagen, grid.5254.6, KU

Countries

Denmark

Continents

Europe

Description

Exercise improves functional capacity and patient-reported outcomes across a range of cancer diagnoses. The mechanisms behind this protection have been largely unknown, but exercise-mediated changes in body composition, sex hormone levels, systemic inflammation, and immune cell function have been suggested to play a role. We recently demonstrated that voluntary exercise leads to an influx of immune cells in tumors, and a more than 60% reduction in tumor incidence and growth across several mouse models. Given the common mechanisms of immune cell mobilization in mouse and man during exercise, we hypothesize that this link between exercise and the immune system can be exploited in cancer therapy in particular in combination with immunotherapy. Thus, we believe that exercise may not just be "healthy" but may in fact be therapeutic.

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NORA University Profiles

University of Copenhagen

Danish Open Access Indicator

2017: Realized

Research area: Medicine

Danish Bibliometrics Indicator

2017: Level 1

Research area: Medicine

Dimensions Citation Indicators

Times Cited: 24

Field Citation Ratio (FCR): 5.43

Relative Citation ratio (RCR): 1.75

Open Access Info

Hybrid