Article open access publication

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Nature Genetics, Springer Nature, ISSN 1061-4036

Volume 49, 5, 2017

DOI:10.1038/ng.3826, Dimensions: pub.1084129162, PMC: PMC5612337, PMID: 28346442,

Authors

Dicks, Ed (3)
Aben, Katja K H (10) (11)
Benitez, Javier (31) (32)
Bjorge, Line (36) (37)
Borg, Åke (44)
Campbell, Ian (55) (56)
Chiew, Yoke-Eng (62) (63)
Dao, Fanny (74)
DeFazio, Anna (62) (63)
Edwards, Todd (29) (30)
Eeles, Ros (85)
Fasching, Peter A (28) (91)
Friedman, Eitan (98) (99)
Garber, Judy (100)
García, María J (31) (32)
Giles, Graham G (48) (55) (104)
Hahnen, Eric (111)
Hauke, Jan (111)
Høgdall, Estrid (116) (117)
Hung, Jillian (62) (63)
Huntsman, David G (47) (121)
James, Paul (55) (56)
Janavicius, Ramunas (126) (127)
Karnezis, Anthony (47) (121)
Kast, Karin (131)
Kjaer, Susanne K (115) (117)
Kopperud, Reidun K (36) (37)
Kwong, Ava (135) (136) (137)
Laitman, Yael (98) (99)
Lambrechts, Diether (138) (139)
Larrañaga, Nerea (140) (141)
Le, Nhu D (47)
Lesueur, Fabienne (50) (145)
Liang, Dong (146)
Lipworth, Loren (29) (30)
Menon, Usha (102)
Milne, Roger L (48) (55)
Mitchell, Gillian (55) (56)
Modugno, Francesmary (154) (155)
Nussbaum, Robert L (59) (161)
Olah, Edith (162)
Ong, Kai-ren (165)
Papi, Laura (168)
Pearce, Celeste L (110) (169)
Peixoto, Ana (171)
Pike, Malcolm C (74) (110)
Pocza, Timea (162)
Rennert, Gad (180) (181)
Romm, Jane (12)
Salvesen, Helga B (36) (37)
Severi, Gianluca (186) (187) (188) (189)
Side, Lucy E (191)
Sieh, Weiva (150)
Sobol, Hagay (192)
Tan, Yen Y (173)
Teixeira, Manuel R (171) (196)
Teo, Soo-Hwang (197) (198)
Tischkowitz, Marc (95) (201)
Trichopoulou, Antonia (203) (204)
Tung, Nadine (205)
Tworoger, Shelley S (69) (174)
Vega, Ana (209) (210)
Edwards, Digna Velez (29) (30) (211)
Walker, Lisa (212)
Woo, Michelle (47) (121)
Wu, Xifeng (19)
Wu, Anna H (110)
Ramus, Susan J (217) (218)
Park, Sue K (220)

* Corresponding author

Affiliations

Organisations

  1. (1) Moffitt Cancer Center, grid.468198.a
  2. (2) Wellcome Sanger Institute, grid.10306.34
  3. (3) University of Cambridge, grid.5335.0
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  9. (9) Academic Medical Center, grid.5650.6
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  20. (20) Karolinska Institute, grid.4714.6
  21. (21) Fondazione IRCCS Istituto Nazionale dei Tumori, grid.417893.0
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  27. (27) Oregon Health & Science University, grid.5288.7
  28. (28) Department of Gynecology and Obstetrics, Universtiy Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany
  29. (29) Vanderbilt University, grid.152326.1
  30. (30) Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, Tennessee, USA
  31. (31) Spanish National Cancer Research Centre, grid.7719.8
  32. (32) Centre for Biomedical Network Research on Rare Diseases, grid.452372.5
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  36. (36) Haukeland University Hospital, grid.412008.f
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  38. (38) National Cancer Institute, grid.48336.3a
  39. (39) Clinical Cancer Genetics for the City of Hope, Clinical Cancer Genetics Community Research Network, Duarte, California, USA
  40. (40) Maastricht University Medical Centre, grid.412966.e
  41. (41) Hannover Medical School, grid.10423.34
  42. (42) Vejle Sygehus, grid.417271.6, Southern Denmark Region
  43. (43) European Institute of Oncology, grid.15667.33
  44. (44) Skåne University Hospital, grid.411843.b
  45. (45) Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
  46. (46) Royal Devon and Exeter Hospital, grid.416118.b
  47. (47) BC Cancer Agency, grid.248762.d
  48. (48) Cancer Council Victoria, grid.3263.4
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  50. (50) Institute Curie, grid.418596.7
  51. (51) Helsinki University Central Hospital, grid.15485.3d
  52. (52) Huntsman Cancer Institute, grid.479969.c
  53. (53) Hospital Clínico San Carlos, grid.411068.a
  54. (54) Azienda Ospedaliera Universitaria Pisana, grid.144189.1
  55. (55) University of Melbourne, grid.1008.9
  56. (56) Peter MacCallum Cancer Centre, grid.1055.1
  57. (57) Roswell Park Cancer Institute, grid.240614.5
  58. (58) University of Hawaii at Manoa, grid.410445.0
  59. (59) University of California, San Francisco, grid.266102.1
  60. (60) University Cancer Center Hamburg, grid.412315.0
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  81. (81) University of Valladolid, grid.5239.d
  82. (82) Department of Gynecology, Jena University Hospital–Friedrich Schiller University, Jena, Germany
  83. (83) University of Bonn, grid.10388.32
  84. (84) University Hospital Southampton NHS Foundation Trust, grid.430506.4
  85. (85) Oncogenetics Team, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK
  86. (86) Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  87. (87) University of Erlangen-Nuremberg, grid.5330.5
  88. (88) Department of Biostatistics and Bioinformatics, Roswell Park Institute, Buffalo, New York, USA
  89. (89) Leipzig University, grid.9647.c
  90. (90) University of Manchester, grid.5379.8
  91. (91) University of California, Los Angeles, grid.19006.3e
  92. (92) Centre Hospitalier Métropole Savoie, grid.418064.f
  93. (93) Imperial College London, grid.7445.2
  94. (94) National Centre of Scientific Research Demokritos, grid.6083.d
  95. (95) McGill University, grid.14709.3b
  96. (96) Aristotle University of Thessaloniki, grid.4793.9
  97. (97) University of Kansas Medical Center, grid.412016.0
  98. (98) Sheba Medical Center, grid.413795.d
  99. (99) Tel Aviv University, grid.12136.37
  100. (100) Dana-Farber Cancer Institute, grid.65499.37
  101. (101) University of Würzburg, grid.8379.5
  102. (102) University College London, grid.83440.3b
  103. (103) Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  104. (104) Monash University, grid.1002.3
  105. (105) Beatson West of Scotland Cancer Centre, grid.422301.6
  106. (106) Mount Sinai Hospital, grid.416166.2
  107. (107) University of Utah, grid.223827.e
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  109. (109) Pomeranian Medical University, grid.107950.a
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  111. (111) University Hospital Cologne, grid.411097.a
  112. (112) Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  113. (113) Institute of Genetic Medicine, Centre for Life, Newcastle-upon-Tyne Hospitals NHS Trust, Newcastle-upon-Tyne, UK
  114. (114) St George's, University of London, grid.264200.2
  115. (115) Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  116. (116) University of Copenhagen, grid.5254.6, KU
  117. (117) Danish Cancer Society, grid.417390.8
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  122. (122) Institute of Oncology NN Petrov, grid.465337.0
  123. (123) Georgetown University Medical Center, grid.411667.3
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  129. (129) Cancer Prevention Institute of California, grid.280669.3
  130. (130) Institute of Cancer Research, grid.18886.3f
  131. (131) Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
  132. (132) Seoul St. Mary's Hospital, grid.414966.8
  133. (133) University of Calgary, grid.22072.35
  134. (134) Odense University Hospital, grid.7143.1, Southern Denmark Region
  135. (135) Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong
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  140. (140) CIBER of Epidemiology and Public Health, Madrid, Spain
  141. (141) Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia–San Sebastian, Spain
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  148. (148) Department of Gynecology, Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  149. (149) Cancer Center of Lyon, grid.462282.8
  150. (150) Stanford University, grid.168010.e
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  160. (160) Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
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  162. (162) National Institute of Oncology, grid.419617.c
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  164. (164) Department of Obstetrics and Gynecology, Ohio State University and the James Cancer Center, Columbus, Ohio, USA
  165. (165) West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK
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  169. (169) University of Michigan, grid.214458.e
  170. (170) Aalborg Hospital, grid.27530.33, North Denmark Region
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  172. (172) IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy
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Description

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.

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Research area: Medicine

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Research area: Medicine

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Times Cited: 119

Field Citation Ratio (FCR): 30.65

Relative Citation ratio (RCR): 6.74

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