Article
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
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- (4) Cedars-Sinai Medical Center, grid.50956.3f
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- (6) Duke University Hospital, grid.189509.c
- (7) QIMR Berghofer Medical Research Institute, grid.1049.c
- (8) Laval University, grid.23856.3a
- (9) Academic Medical Center, grid.5650.6
- (10) Netherlands Comprehensive Cancer Organisation, grid.470266.1
- (11) Radboud University Nijmegen Medical Centre, grid.10417.33
- (12) Johns Hopkins University, grid.21107.35
- (13) Chapel Allerton Hospital, grid.413818.7
- (14) University of Toronto, grid.17063.33
- (15) University of California, Irvine, grid.266093.8
- (16) N.N. Alexandrov National Cancer Centre, grid.477553.7
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- (19) The University of Texas MD Anderson Cancer Center, grid.240145.6
- (20) Karolinska Institute, grid.4714.6
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- (22) Hospital Universitari Vall d'Hebron, grid.411083.f
- (23) Royal Marsden Hospital, grid.424926.f
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- (25) National University Hospital of Iceland, grid.410540.4
- (26) University of Iceland, grid.14013.37
- (27) Oregon Health & Science University, grid.5288.7
- (28) Department of Gynecology and Obstetrics, Universtiy Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany
- (29) Vanderbilt University, grid.152326.1
- (30) Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, Tennessee, USA
- (31) Spanish National Cancer Research Centre, grid.7719.8
- (32) Centre for Biomedical Network Research on Rare Diseases, grid.452372.5
- (33) Russian Academy of Sciences, grid.4886.2
- (34) Princess Margaret Cancer Centre, grid.415224.4
- (35) Massachusetts General Hospital, grid.32224.35
- (36) Haukeland University Hospital, grid.412008.f
- (37) University of Bergen, grid.7914.b
- (38) National Cancer Institute, grid.48336.3a
- (39) Clinical Cancer Genetics for the City of Hope, Clinical Cancer Genetics Community Research Network, Duarte, California, USA
- (40) Maastricht University Medical Centre, grid.412966.e
- (41) Hannover Medical School, grid.10423.34
- (42) Vejle Sygehus, grid.417271.6, Southern Denmark Region
- (43) European Institute of Oncology, grid.15667.33
- (44) Skåne University Hospital, grid.411843.b
- (45) Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
- (46) Royal Devon and Exeter Hospital, grid.416118.b
- (47) BC Cancer Agency, grid.248762.d
- (48) Cancer Council Victoria, grid.3263.4
- (49) Catalan Institute of Oncology, grid.418701.b
- (50) Institute Curie, grid.418596.7
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- (52) Huntsman Cancer Institute, grid.479969.c
- (53) Hospital Clínico San Carlos, grid.411068.a
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- (55) University of Melbourne, grid.1008.9
- (56) Peter MacCallum Cancer Centre, grid.1055.1
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- (58) University of Hawaii at Manoa, grid.410445.0
- (59) University of California, San Francisco, grid.266102.1
- (60) University Cancer Center Hamburg, grid.412315.0
- (61) German Cancer Research Center, grid.7497.d
- (62) University of Sydney, grid.1013.3
- (63) Westmead Hospital, grid.413252.3
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- (65) Columbia University, grid.21729.3f
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- (67) University of New Mexico, grid.266832.b
- (68) Sheffield Children's Hospital, grid.413991.7
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- (74) Memorial Sloan Kettering Cancer Center, grid.51462.34
- (75) University of Glasgow, grid.8756.c
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- (77) City Of Hope National Medical Center, grid.410425.6
- (78) Dartmouth College, grid.254880.3
- (79) University of Pretoria, grid.49697.35
- (80) International Agency For Research On Cancer, grid.17703.32
- (81) University of Valladolid, grid.5239.d
- (82) Department of Gynecology, Jena University Hospital–Friedrich Schiller University, Jena, Germany
- (83) University of Bonn, grid.10388.32
- (84) University Hospital Southampton NHS Foundation Trust, grid.430506.4
- (85) Oncogenetics Team, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK
- (86) Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
- (87) University of Erlangen-Nuremberg, grid.5330.5
- (88) Department of Biostatistics and Bioinformatics, Roswell Park Institute, Buffalo, New York, USA
- (89) Leipzig University, grid.9647.c
- (90) University of Manchester, grid.5379.8
- (91) University of California, Los Angeles, grid.19006.3e
- (92) Centre Hospitalier Métropole Savoie, grid.418064.f
- (93) Imperial College London, grid.7445.2
- (94) National Centre of Scientific Research Demokritos, grid.6083.d
- (95) McGill University, grid.14709.3b
- (96) Aristotle University of Thessaloniki, grid.4793.9
- (97) University of Kansas Medical Center, grid.412016.0
- (98) Sheba Medical Center, grid.413795.d
- (99) Tel Aviv University, grid.12136.37
- (100) Dana-Farber Cancer Institute, grid.65499.37
- (101) University of Würzburg, grid.8379.5
- (102) University College London, grid.83440.3b
- (103) Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
- (104) Monash University, grid.1002.3
- (105) Beatson West of Scotland Cancer Centre, grid.422301.6
- (106) Mount Sinai Hospital, grid.416166.2
- (107) University of Utah, grid.223827.e
- (108) National Institutes of Health, grid.94365.3d
- (109) Pomeranian Medical University, grid.107950.a
- (110) University of Southern California, grid.42505.36
- (111) University Hospital Cologne, grid.411097.a
- (112) Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
- (113) Institute of Genetic Medicine, Centre for Life, Newcastle-upon-Tyne Hospitals NHS Trust, Newcastle-upon-Tyne, UK
- (114) St George's, University of London, grid.264200.2
- (115) Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
- (116) University of Copenhagen, grid.5254.6, KU
- (117) Danish Cancer Society, grid.417390.8
- (118) Antoni van Leeuwenhoek Hospital, grid.430814.a
- (119) Erasmus University Medical Center, grid.5645.2
- (120) NorthShore University HealthSystem, grid.240372.0
- (121) University of British Columbia, grid.17091.3e
- (122) Institute of Oncology NN Petrov, grid.465337.0
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- (124) Duke University, grid.26009.3d
- (125) Guy's and St Thomas' NHS Foundation Trust, grid.420545.2
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- (127) Vilnius University Hospital Santariskiu Klinikos, grid.426597.b
- (128) Aarhus University Hospital, grid.154185.c, Central Denmark Region
- (129) Cancer Prevention Institute of California, grid.280669.3
- (130) Institute of Cancer Research, grid.18886.3f
- (131) Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
- (132) Seoul St. Mary's Hospital, grid.414966.8
- (133) University of Calgary, grid.22072.35
- (134) Odense University Hospital, grid.7143.1, Southern Denmark Region
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- (137) University of Hong Kong, grid.194645.b
- (138) Flanders Institute for Biotechnology, grid.11486.3a
- (139) KU Leuven, grid.5596.f
- (140) CIBER of Epidemiology and Public Health, Madrid, Spain
- (141) Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia–San Sebastian, Spain
- (142) Institut d'Investigació Biomédica de Bellvitge, grid.418284.3
- (143) Asan Medical Center, grid.413967.e
- (144) Centre Hospitalier Universitaire de Grenoble, grid.410529.b
- (145) Mines Paris Tech, Fontainebleau, France
- (146) Texas Southern University, grid.264771.1
- (147) Cancer Center Wolfsburg, Clinics of Gynaecology, Wolfsburg, Germany
- (148) Department of Gynecology, Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
- (149) Cancer Center of Lyon, grid.462282.8
- (150) Stanford University, grid.168010.e
- (151) Public Health Ontario, grid.415400.4
- (152) VU University Medical Center, grid.16872.3a
- (153) Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
- (154) University of Pittsburgh, grid.21925.3d
- (155) University of Pittsburgh Cancer Institute, grid.478063.e
- (156) Istituto Oncologico Veneto, grid.419546.b
- (157) St. Michael's Hospital, grid.415502.7
- (158) Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
- (159) The University of Texas Health Science Center at Houston, grid.267308.8
- (160) Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
- (161) Invitae Corporation, San Francisco, California, USA
- (162) National Institute of Oncology, grid.419617.c
- (163) University of Chicago Medical Center, grid.412578.d
- (164) Department of Obstetrics and Gynecology, Ohio State University and the James Cancer Center, Columbus, Ohio, USA
- (165) West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK
- (166) University Medical Center Utrecht, grid.7692.a
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- (168) University of Florence, grid.8404.8
- (169) University of Michigan, grid.214458.e
- (170) Aalborg Hospital, grid.27530.33, North Denmark Region
- (171) Portuguese Oncology Institute, grid.418711.a
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- (173) Department of Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Vienna, Austria
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- (175) Western General Hospital, grid.417068.c
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- (177) Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain
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- (182) Department of Pathology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
- (183) Fred Hutchinson Cancer Research Center, grid.270240.3
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- (189) University of Paris-Sud, grid.5842.b
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- (193) University of South Florida, grid.170693.a
- (194) University Hospital Heidelberg, grid.5253.1
- (195) National Human Genome Research Institute, grid.280128.1
- (196) University of Porto, grid.5808.5
- (197) Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia
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- (199) Magee-Womens Hospital of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
- (200) Latvian Biomedical Research and Study Centre, grid.419210.f
- (201) Addenbrooke's Hospital, grid.120073.7
- (202) University of Oxford, grid.4991.5
- (203) Hellenic Health Foundation, grid.424637.0
- (204) National and Kapodistrian University of Athens, grid.5216.0
- (205) Beth Israel Deaconess Medical Center, grid.239395.7
- (206) Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
- (207) Universitair Ziekenhuis Leuven, grid.410569.f
- (208) Charité, grid.6363.0
- (209) Fundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde (SERGAS), Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain
- (210) University of Santiago de Compostela, grid.11794.3a
- (211) Vanderbilt University Medical Center, grid.412807.8
- (212) Churchill Hospital, grid.415719.f
- (213) University Hospital Leipzig, grid.411339.d
- (214) University of Ulm, grid.6582.9
- (215) Leiden University Medical Center, grid.10419.3d
- (216) University of Virginia, grid.27755.32
- (217) Garvan Institute of Medical Research, grid.415306.5
- (218) UNSW Sydney, grid.1005.4
- (219) Sapienza University of Rome, grid.7841.a
- (220) Seoul National University, grid.31501.36
- (221) Medical University of South Carolina, grid.259828.c
- (222) Yale University, grid.47100.32
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To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
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