Article open access publication

Biochemistry of malaria parasite infected red blood cells by X-ray microscopy

Scientific Reports, Springer Nature, ISSN 2045-2322

Volume 7, 1, 2017

DOI:10.1038/s41598-017-00921-2, Dimensions: pub.1084537951, PMC: PMC5429762, PMID: 28400621,

Authors

Yang, Y. (3)

* Corresponding author

Affiliations

Organisations

  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) Weizmann Institute of Science, grid.13992.30
  3. (3) European Synchrotron Radiation Facility, grid.5398.7
  4. (4) ALBA Synchrotron (Spain), grid.423639.9
  5. (5) Humboldt University of Berlin, grid.7468.d

Countries

Germany

France

Spain

Israel

Denmark

Continents

Europe

Asia

Description

Red blood cells infected by the malaria parasite Plasmodium falciparum are correlatively imaged by tomography using soft X-rays as well as by scanning hard nano-X-ray beam to obtain fluorescence maps of various elements such as S and Fe. In this way one can deduce the amount of Fe bound either in hemoglobin or in hemozoin crystals in the digestive vacuole of the malaria parasite as well as determine the hemoglobin concentrations in the cytosols of the red blood cell and of the parasite. Fluorescence map of K shows that in the parasite's schizont stage the K concentration in the red blood cell cytosol is diminished by a factor of seven relative to a pristine red blood cell but the total amount of K in the infected red blood cell is the same as in the pristine red blood cell.

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Research area: Science & Technology

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Field Citation Ratio (FCR): 3.92

Relative Citation ratio (RCR): 0.76

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