Article

Wake and light therapy for moderate‐to‐severe depression – a randomized controlled trial

Acta Psychiatrica Scandinavica, Wiley, ISSN 0001-690X

Volume 136, 6, 2017

DOI:10.1111/acps.12741, Dimensions: pub.1084939018, PMID: 28422269,

Affiliations

Organisations

  1. (1) Aarhus University Hospital, grid.154185.c, Central Denmark Region
  2. (2) Mental Health Services, grid.466916.a, Central Denmark Region
  3. (3) Rigshospitalet, grid.475435.4, Capital Region
  4. (4) Copenhagen University Hospital Department of Internal Medicine Herlev Denmark

Countries

Denmark

Continents

Europe

Description

OBJECTIVE: To examine the efficacy of using wake and light therapy as a supplement to standard treatment of hospitalized patients with depression. METHOD: In this randomized, controlled study, 64 patients with moderate-to-severe depression were allocated to standard treatment or to the intervention, which additionally consisted of three wake therapy sessions in one week, 30-min daily light treatment and sleep time stabilization over the entire nine-week study period. RESULTS: Patients in the wake therapy group had a significant decrease in depressive symptoms in week one as measured by HAM-D17 , 17.39 (CI 15.6-19.2) vs. 20.19 (CI 18.3-22.09) (P = 0.04), whereas no statistically significant differences were found between the groups in weeks two to nine. At week nine, the wake therapy group had a significantly larger increase in general self-efficacy (P = 0.001), and waking up during nights was a significantly less frequent problem (1.9 times vs. 3.2) (P = 0.0008). In most weeks, significantly fewer patients in the wake therapy group slept during the daytime, and if they slept, their naps were shorter (week three: 66 min vs. 117 min P = 0.02). CONCLUSION: The antidepressant effect initially achieved could not be maintained during the nine-week study period. However, sleep and general self-efficacy improved.

Funders

Research Categories

Main Subject Area

Fields of Research

Links & Metrics

NORA University Profiles

Aarhus University

Dimensions Citation Indicators

Times Cited: 11

Field Citation Ratio (FCR): 6.12

Relative Citation ratio (RCR): 1.12