Preprint open access publication

Psychiatric Genomics: An Update and an Agenda

bioRxiv, Cold Spring Harbor Laboratory,


DOI:10.1101/115600, Dimensions: pub.1085103218,



  1. (1) University of North Carolina at Chapel Hill, grid.10698.36
  2. (2) Karolinska Institute, grid.4714.6
  3. (3) University of North Carolina System, grid.410711.2
  4. (4) Washington University in St. Louis, grid.4367.6
  5. (5) Oslo University Hospital, grid.55325.34
  6. (6) Aarhus University, grid.7048.b, AU
  7. (7) Lundbeck Foundation, grid.452548.a
  8. (8) King's College London, grid.13097.3c
  9. (9) National Institute for Health Research, grid.451056.3
  10. (10) Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland; Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, Bonn, Germany; Institute of Neuroscience and Medicine (INM-1), Juelich, Germany
  11. (11) University of Basel, grid.6612.3
  12. (12) University of Bonn, grid.10388.32
  13. (13) Indiana University – Purdue University Indianapolis, grid.257413.6
  14. (14) SUNY Upstate Medical University, grid.411023.5
  15. (15) University of Bergen, grid.7914.b
  16. (16) Yale University, grid.47100.32
  17. (17) University of Florida, grid.15276.37
  18. (18) University of California, San Diego, grid.266100.3
  19. (19) Massachusetts General Hospital, grid.32224.35
  20. (20) Cardiff University, grid.5600.3


Abstract The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. In the past decade, this global effort has delivered a rapidly increasing flow of new knowledge about the fundamental basis of common psychiatric disorders, particularly given its dedication to rapid progress and open science. The PGC has recently commenced a program of research designed to deliver “actionable” findings - genomic results that (a) reveal the fundamental biology, (b) inform clinical practice, and (c) deliver new therapeutic targets. This is the central idea of the PGC: to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights. The emerging findings suggest that we are entering into a phase of accelerated translation of genetic discoveries to impact psychiatric practice within a precision medicine framework. Collaborators PGC Coordinating Committee: Mark Daly, Michael Gill, John Kelsoe, Karestan Koenen, Douglas Levinson, Cathryn Lewis, Ben Neale, Danielle Posthuma, Jonathan Sebat, and Pamela Sklar.


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