Article open access publication

A novel community driven software for functional enrichment analysis of extracellular vesicles data

Journal of Extracellular Vesicles, Taylor & Francis, ISSN 2001-3078

Volume 6, 1, 2017

DOI:10.1080/20013078.2017.1321455, Dimensions: pub.1085663085, PMC: PMC5505018, PMID: 28717418,



  1. (1) La Trobe University, grid.1018.8
  2. (2) University of Palermo, grid.10776.37
  3. (3) University of Melbourne, grid.1008.9
  4. (4) Yale University, grid.47100.32
  5. (5) Bioinformatics Institute, grid.418325.9
  6. (6) Cornell University, grid.5386.8
  7. (7) University of Turin, grid.7605.4
  8. (8) Cardiff University, grid.5600.3
  9. (9) Department of Medical Science, University of Torino, Medical School, Torino, Italy; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, View further author information
  10. (10) Cedars-Sinai Medical Center, grid.50956.3f
  11. (11) CIC bioGUNE, grid.420175.5
  12. (12) Karolinska University Hospital, grid.24381.3c
  13. (13) Pohang University of Science and Technology, grid.49100.3c
  14. (14) Ghent University, grid.5342.0
  15. (15) Utrecht University, grid.5477.1
  16. (16) Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Catania, Italy; Department of Clinical Neurosciences, Wellcome Trust-Medical Research Council Stem Cell Institute and National Institute for Health Research Biomedical Research Centre, University of Cambridge, Cambridge, UK,, View further author information
  17. (17) Aalborg University, grid.5117.2, AAU
  18. (18) Princess Margaret Cancer Centre, grid.415224.4
  19. (19) Institute Curie, grid.418596.7
  20. (20) University of Cambridge, grid.5335.0
  21. (21) Icahn School of Medicine at Mount Sinai, grid.59734.3c
  22. (22) Oslo University Hospital, grid.55325.34
  23. (23) University of Gothenburg, grid.8761.8
  24. (24) Mayo Clinic, grid.417467.7
  25. (25) Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA; Microenvironment and Metastasis Group, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, Spain,, View further author information
  26. (26) Uppsala University, grid.8993.b
  27. (27) Cardiff Metropolitan University, grid.47170.35


Bioinformatics tools are imperative for the in depth analysis of heterogeneous high-throughput data. Most of the software tools are developed by specific laboratories or groups or companies wherein they are designed to perform the required analysis for the group. However, such software tools may fail to capture "what the community needs in a tool". Here, we describe a novel community-driven approach to build a comprehensive functional enrichment analysis tool. Using the existing FunRich tool as a template, we invited researchers to request additional features and/or changes. Remarkably, with the enthusiastic participation of the community, we were able to implement 90% of the requested features. FunRich enables plugin for extracellular vesicles wherein users can download and analyse data from Vesiclepedia database. By involving researchers early through community needs software development, we believe that comprehensive analysis tools can be developed in various scientific disciplines.


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2017: Realized

Research area: Medicine

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Times Cited: 99

Field Citation Ratio (FCR): 19.86

Relative Citation ratio (RCR): 8.61

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