Article open access publication

The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium

Cancer Epidemiology Biomarkers & Prevention, American Association for Cancer Research (AACR), ISSN 1055-9965

Volume 26, 9, 2017

DOI:10.1158/1055-9965.epi-17-0246, Dimensions: pub.1085969517, PMC: PMC5581673, PMID: 28600297,



  1. (1) University of North Carolina at Chapel Hill, grid.10698.36
  2. (2) Institute of Cancer Research, grid.18886.3f
  3. (3) Karolinska Institute, grid.4714.6
  4. (4) Fondazione IRCCS Istituto Nazionale dei Tumori, grid.417893.0
  5. (5) Centre for research in epidemiology and population health, grid.463845.8
  6. (6) City Of Hope National Medical Center, grid.410425.6
  7. (7) Boston University, grid.189504.1
  8. (8) Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
  9. (9) University of Pittsburgh, grid.21925.3d
  10. (10) New York University, grid.137628.9
  11. (11) National Institute of Arthritis and Musculoskeletal and Skin Diseases, grid.420086.8
  12. (12) International Agency For Research On Cancer, grid.17703.32
  13. (13) Brigham and Women's Hospital, grid.62560.37
  14. (14) University of Melbourne, grid.1008.9
  15. (15) The Arctic University of Norway, grid.10919.30
  16. (16) University of Massachusetts Boston, grid.266685.9
  17. (17) Johns Hopkins University, grid.21107.35
  18. (18) German Cancer Research Center, grid.7497.d
  19. (19) University of Oxford, grid.4991.5
  20. (20) University of Toronto, grid.17063.33
  21. (21) Duke NUS Graduate Medical School, grid.428397.3
  22. (22) Imperial College London, grid.7445.2
  23. (23) Instituto Murciano de Investigación Biosanitaria, grid.452553.0
  24. (24) University of Murcia, grid.10586.3a
  25. (25) Aarhus University, grid.7048.b, AU
  26. (26) Radiation Effects Research Foundation, grid.418889.4
  27. (27) University Medical Center Utrecht, grid.7692.a
  28. (28) Albert Einstein College of Medicine, grid.251993.5
  29. (29) Umeå University, grid.12650.30
  30. (30) Hellenic Health Foundation, grid.424637.0
  31. (31) Norwegian University of Science and Technology, grid.5947.f
  32. (32) Cancer Registry of Norway, grid.418941.1
  33. (33) Folkhälsans Forskningscentrum, grid.428673.c
  34. (34) Karolinska Institutet, Department of Epidemiology and Biostatistics, Oslo, Norway.
  35. (35) Harvard University, grid.38142.3c
  36. (36) National Institute of Environmental Health Sciences, grid.280664.e


Breast cancer is a leading cancer diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence rates of advanced breast cancer have increased in recent decades for premenopausal women. Progress in identifying contributors to breast cancer risk among premenopausal women has been constrained by the limited numbers of premenopausal breast cancer cases in individual studies and resulting low statistical power to subcategorize exposures or to study specific subtypes. The Premenopausal Breast Cancer Collaborative Group was established to facilitate cohort-based analyses of risk factors for premenopausal breast cancer by pooling individual-level data from studies participating in the United States National Cancer Institute Cohort Consortium. This article describes the Group, including the rationale for its initial aims related to pregnancy, obesity, and physical activity. We also describe the 20 cohort studies with data submitted to the Group by June 2016. The infrastructure developed for this work can be leveraged to support additional investigations. Cancer Epidemiol Biomarkers Prev; 26(9); 1360-9. ©2017 AACR.


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