Article open access publication

Grazoprevir, ruzasvir, and uprifosbuvir for hepatitis C virus after NS5A treatment failure

Hepatology, Wiley, ISSN 0270-9139

Volume 66, 6, 2017

DOI:10.1002/hep.29358, Dimensions: pub.1090387950, PMID: 28688129,



  1. (1) University of Colorado Denver, grid.241116.1
  2. (2) Hannover Medical School, grid.10423.34
  3. (3) Sheba Medical Center, grid.413795.d
  4. (4) Auckland City Hospital, grid.414055.1
  5. (5) Aalborg Hospital, grid.27530.33, North Denmark Region
  6. (6) Icahn School of Medicine at Mount Sinai, grid.59734.3c
  7. (7) Mount Sinai Beth Israel and Icahn School of Medicine at Mount Sinai, New York, NY
  8. (8) Aarhus University Hospital, grid.154185.c, Central Denmark Region
  9. (9) University of California, San Francisco, grid.266102.1
  10. (10) ID Care, Hillsborough, NJ
  11. (11) Monash Medical Centre, grid.416060.5
  12. (12) University Hospital Frankfurt, grid.411088.4
  13. (13) MSD (United States), grid.417993.1
  14. (14) Service d'Hépatologie, Hôpital Saint‐Antoine, Université Pierre & Marie Curie, Paris, France


People with hepatitis C virus (HCV) infection who have failed treatment with an all-oral regimen represent a challenging treatment population. The present studies evaluated the safety and efficacy of grazoprevir, ruzasvir, and uprifosbuvir, with or without ribavirin, in participants who had failed an NS5A inhibitor-containing regimen. C-SURGE (PN-3682-021) and C-CREST Part C (PN-3682-011 and -012) were open-label, multicenter studies. Participants who had previously relapsed following an NS5A inhibitor-containing all-oral regimen were retreated with grazoprevir 100 mg, ruzasvir 60 mg, and uprifosbuvir 450 mg alone for 24 weeks or with ribavirin for 16 weeks. The primary efficacy endpoint was sustained virologic response (HCV RNA below the limit of quantitation [<15 IU/mL]) 12 weeks after treatment completion (SVR12). In C-SURGE, SVR12 was achieved by 49/49 (100%) and 43/44 (98%) genotype (GT)1 participants in the 24-week no ribavirin arm and the 16-week plus ribavirin arm (lost to follow-up, n = 1), respectively. In C-CREST Part C, SVR12 was achieved by 23/24 (96%) participants treated for 16 weeks with ribavirin (GT1, 2/2 [100%]; GT2, 13/14 [93%]; GT3, 8/8 [100%]). One participant with GT2 infection discontinued study medication after a single dose of grazoprevir, ruzasvir, and uprifosbuvir plus ribavirin due to serious adverse events of vomiting and tachycardia. The presence of baseline resistance-associated substitutions had no impact on SVR12. No participant who completed treatment in either study experienced virologic failure. CONCLUSION: Grazoprevir, ruzasvir, and uprifosbuvir, with or without ribavirin, for 16 or 24 weeks was safe and highly effective in participants with HCV infection who had previously failed NS5A inhibitor-containing therapy. (Hepatology 2017;66:1794-1804).

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2017: Unused

Research area: Medicine

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2017: Level 2

Research area: Medicine

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