Article open access publication

EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice

Molecular and Cellular Biology, American Society for Microbiology, ISSN 1098-5549

Volume 37, 19, 2017

DOI:10.1128/mcb.00082-17, Dimensions: pub.1090619039, PMC: PMC5599718, PMID: 28694333,

Affiliations

Organisations

  1. (1) Japan Science and Technology Agency, grid.419082.6
  2. (2) RIKEN Center for Integrative Medical Science, Yokohama, Kanagawa, Japan
  3. (3) Yokohama City University, grid.268441.d
  4. (4) Chiba University, grid.136304.3
  5. (5) University of Copenhagen, grid.5254.6, KU
  6. (6) RIKEN, grid.7597.c
  7. (7) National Cancer Centre, grid.272242.3

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Denmark

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Asia

Europe

Description

Global histone hyperacetylation is suggested to play a critical role for replacement of histones by transition proteins and protamines to compact the genome during spermiogenesis. However, the underlying mechanisms for hyperacetylation-mediated histone replacement remains poorly understood. Here, we report that EPC1 and TIP60, two critical components of the mammalian nucleosome acetyltransferase of H4 (NuA4) complexes, are coexpressed in male germ cells. Strikingly, genetic ablation of either Epc1 or Tip60 disrupts hyperacetylation and impairs histone replacement, in turn causing aberrant spermatid development. Taking these observations together, we reveal an essential role of the NuA4 complexes for histone hyperacetylation and subsequent compaction of the spermatid genome.

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University of Copenhagen

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Times Cited: 10

Field Citation Ratio (FCR): 5.52

Relative Citation ratio (RCR): 0.91

Open Access Info

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