Article open access publication

Maternal expression of the JMJD2A/KDM4A histone demethylase is critical for pre-implantation development

Development, The Company of Biologists, ISSN 0950-1991

Volume 144, 18, 2017

DOI:10.1242/dev.155473, Dimensions: pub.1091289589, PMID: 28827393,

Affiliations

Organisations

  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) University of Turku, grid.1374.1
  3. (3) University of Gothenburg, grid.8761.8

Countries

Denmark

Finland

Sweden

Continents

Europe

Description

Regulation of chromatin composition through post-translational modifications of histones contributes to transcriptional regulation and is essential for many cellular processes, including differentiation and development. KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-methylated lysine 9 and lysine 36 of histone H3 (H3K9me2/me3 and H3K36me2/me3). Here, we report that Kdm4a as a maternal factor plays a key role in embryo survival and is vital for female fertility. Kdm4a-/- female mice ovulate normally with comparable fertilization but poor implantation rates, and cannot support healthy transplanted embryos to term. This is due to a role for Kdm4a in uterine function, where its loss causes reduced expression of key genes involved in ion transport, nutrient supply and cytokine signalling, which impact embryo survival. In addition, a significant proportion of Kdm4a-deficient oocytes displays a poor intrinsic ability to develop into blastocysts. These embryos cannot compete with healthy embryos for implantation in vivo, highlighting Kdm4a as a maternal effect gene. Thus, our study dissects an important dual role for maternal Kdm4a in determining faithful early embryonic development and the implantation process.

Funders

Research Categories

Main Subject Area

Links & Metrics

NORA University Profiles

University of Copenhagen

Dimensions Citation Indicators

Times Cited: 14

Field Citation Ratio (FCR): 4.13

Relative Citation ratio (RCR): 0.98

Open Access Info

Bronze