Article open access publication

Animal models for evaluation of oral delivery of biopharmaceuticals

Journal of Controlled Release, Elsevier, ISSN 1873-4995

Volume 268, 2017

DOI:10.1016/j.jconrel.2017.09.025, Dimensions: pub.1091864564, PMID: 28935596,

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  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) Technical University of Denmark, grid.5170.3, DTU

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Denmark

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Europe

Description

Biopharmaceuticals are increasingly important for patients and the pharmaceutical industry due to their ability to treat and, in some cases, even cure chronic and potentially life-threatening diseases. Most biopharmaceuticals are administered by injection, but intensive focus on development of systems for oral delivery of biopharmaceuticals may result in new treatment modalities to increase the patient compliance and reduce product cost. In the preclinical development phase, use of experimental animal models is essential for evaluation of new formulation designs. In general, the limited oral bioavailability of biopharmaceuticals, of just a few percent, is expected, and therefore, the animal models and the experimental settings must be chosen with utmost care. More knowledge and focus on this topic is highly needed, despite experience from the numerous studies evaluating animal models for oral drug delivery of small molecule drugs. This review highlights and discusses pros and cons of the most currently used animal models and settings. Additionally, it also looks into the influence of anesthetics and sampling methods for evaluation of drug delivery systems for oral delivery of biopharmaceuticals primarily with examples on insulin.

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NORA University Profiles

University of Copenhagen

Technical University of Denmark

Danish Open Access Indicator

2017: Unused

Research area: Medicine

Danish Bibliometrics Indicator

2017: Level 2

Research area: Medicine

Dimensions Citation Indicators

Times Cited: 11

Field Citation Ratio (FCR): 4.42

Relative Citation ratio (RCR): 0.86

Open Access Info

Green, Submitted