Article open access publication

From concept to in vivo testing: Microcontainers for oral drug delivery

Journal of Controlled Release, Elsevier, ISSN 1873-4995

Volume 268, 2017

DOI:10.1016/j.jconrel.2017.10.013, Dimensions: pub.1092274093, PMID: 29054373,

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  1. (1) Technical University of Denmark, grid.5170.3, DTU
  2. (2) University of Copenhagen, grid.5254.6, KU

Countries

Denmark

Continents

Europe

Description

This work explores the potential of polymeric micrometer sized devices (microcontainers) as oral drug delivery systems (DDS). Arrays of detachable microcontainers (D-MCs) were fabricated on a sacrificial layer to improve the handling and facilitate the collection of individual D-MCs. A model drug, ketoprofen, was loaded into the microcontainers using supercritical CO2 impregnation, followed by deposition of an enteric coating to protect the drug from the harsh gastric environment and to provide a fast release in the intestine. In vitro, in vivo and ex vivo studies were performed to assess the viability of the D-MCs as oral DDS. D-MCs improved the relative oral bioavailability by 180% within 4h, and increased the absorption rate by 2.4 times compared to the control. This work represents a significant step forward in the translation of these devices from laboratory to clinic.

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NORA University Profiles

Technical University of Denmark

University of Copenhagen

Danish Open Access Indicator

2017: Realized

Research area: Science & Technology

Danish Bibliometrics Indicator

2017: Level 2

Research area: Science & Technology

Dimensions Citation Indicators

Times Cited: 20

Field Citation Ratio (FCR): 6.16

Relative Citation ratio (RCR): 1.92

Open Access Info

Green, Submitted