Article

Barley beta-glucans varying in molecular mass and oligomer structure affect cecal fermentation and microbial composition but not blood lipid profiles in hypercholesterolemic rats

Food & Function, Royal Society of Chemistry (RSC), ISSN 2042-6496

Volume 8, 12, 2017

DOI:10.1039/c7fo01314k, Dimensions: pub.1092711744, PMID: 29165477,

Authors

Mikkelsen, Mette S. (1) (2) (3) (4)
Jensen, Morten G. (4) (5) (6)
Nielsen, Tina S. (4) (7) (8)

Affiliations

Organisations

  1. (1) Department of Food Science
  2. (2) Faculty of Science
  3. (3) University of Copenhagen, grid.5254.6, KU
  4. (4) Denmark
  5. (5) Carlsberg A/S
  6. (6) Carlsberg Research Laboratory
  7. (7) Aarhus University, grid.7048.b, AU
  8. (8) Department of Animal Science

Countries

Denmark

Continents

Europe

Description

There is an unmet need for appealing and functional barley β-glucan (BG) food matrices that can provide sufficient and active BG doses to consumers. We investigated how molecular mass and oligomer structure important for BG food and health properties affected plasma lipids and gut parameters in hypercholesterolemic rats. Following 3 weeks on a high-cholestrol diet, rats were given a high-cholesterol diet supplemented with either cellulose (control) or purified barley BGs with low (100 or 150 kDa; glucagel or lowBG, respectively) or medium (530 kDa; mediumBG) molecular masses varying in cellotriosyl/cellotetraosyl oligomer ratio for 4 weeks. All four diets (control, glucagel, lowBG or mediumBG) reduced plasma triacylglycerol and cholesterols from week 3 to 7. The BG diets increased cecal production of short-chain fatty acids (SCFAs) compared to the control diet. The glucagel and lowBG diets stimulated the number of Bifidobacterium in the cecum, whereas the mediumBG diet reduced numbers of both Bacteroides/Prevotella and Lactobacillus in the cecum compared to the control diet. In conclusion, barley BGs at 6.5-7.5% of the diet independent of molecular mass and oligomer block structure showed no additional effect compared to the control treatment on blood cholesterol and triacylglycerol levels in this hypercholesterolemic rat model. Furthermore, the cecal fermentation pattern and microbial composition did not seem to affect plasma lipid composition.

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NORA University Profiles

University of Copenhagen

Aarhus University

Danish Open Access Indicator

2017: Unused

Research area: Science & Technology

Danish Bibliometrics Indicator

2017: Level 1

Research area: Science & Technology

Dimensions Citation Indicators

Times Cited: 9

Field Citation Ratio (FCR): 1.8

Relative Citation ratio (RCR): 0.96